Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)

Critical Illness Clinical Trial

Official title: A Double-blinded Randomized Controlled Trial of Dexmedetomidine Versus Propofol for Sedation in Mechanically Ventilated Medical Intensive Care Unit Patients.

Status Terminated

Clinical Trial Summary

This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.

Clinical Trial Description

Mechanically ventilated critically ill patients are routinely given sedative and analgesic medications to relieve pain and anxiety associated with intubation, mechanical ventilation, and critical care in general. While integral in minimizing discomfort, these medications may increase mechanical ventilation time, the duration of intensive care unit (ICU) stay, ICU complications (e.g. delirium, ventilator associated pneumonia, venous thromboembolism), the morbidity associated with critical illness, and patient mortality. This study compares two sedative medications that have been used in patients who require a mechanical ventilator. Enrolled patients will be randomly assigned to receive propofol or dexmedetomidine for sedation while they require ventilatory support. All patients will also receive the pain medication fentanyl as needed. ;

Related Conditions & MeSH terms

• Critical Illness
• Mechanical Ventilation

• NCT number: NCT01059929
• Study type: Interventional
• Source: University of Chicago
• Status: Terminated
• Phase: Phase 4
• Start date: September 2009
• Completion date: September 2015