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Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment

Critical Care Clinical Trial

Official title:
Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment

Clinical Trial Summary

Background: In patients undergoing hemodialysis or hemofiltration will suffer from the injury of reactive oxidative species. Oxidative stress will affect cell membrane, protein, and DNA. It will damage the cell and result in organ dysfunction. We believe that in patients, who have acute hepatic failure, undergoing plasma exchange or Molecular Absorbent Recirculating System for bridge therapy will suffer from the injury of reactive oxidative species, too. It will damage the kidney, lung, cerebral cortex, and other organs. It may result in death before the recovery of liver function or undergoing liver transplantation.

Aims: 1. Investigate the severity of oxidative stress and risk factors of high oxidative stress in acute hepatic failure patient undergoing plasma exchange or Molecular Absorbent Recirculating System. 2. Investigate the microcirculation status and risk factors in acute hepatic failure patient undergoing plasma exchange or Molecular Absorbent Recirculating System. 3. Study the relationship between oxidative stress and microcirculation status. 4. Study the correlation between oxidative stress and prognosis. 5. Study the correlation between microcirculation status and prognosis.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00772252
Study type Observational
Source National Taiwan University Hospital
Contact Yu-Chang Yeh
Phone 0968661829
Email tonyyeh@ntuh.gov.tw
Status Recruiting
Phase N/A
Start date August 2008
Completion date December 2010
View Details
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