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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03287895
Other study ID # 20170531
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 1, 2017
Est. completion date October 22, 2018

Study information

Verified date December 2018
Source Ottawa Hospital Research Institute
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Objective

The primary objective is to evaluate the efficacy of a multi-faceted, clinical decision support intervention aimed at improving the quality of decisions about Cardio Pulmonary Resuscitation (CPR) for seriously ill, elderly patients in hospital.

The hypothesis is that fewer patients in the intervention group will have a documented order for CPR and they will have greater satisfaction with decision making about CPR than patients in the control group.


Description:

Methodological Approach

The study will be a randomized controlled trial comparing a multi-faceted decision support intervention to usual care for hospitalized patients. The primary objective of this study is to determine if our multifaceted intervention changes decisions about CPR. The components of the multifaceted intervention have already been evaluated for feasibility and acceptability in the hospital setting. The intervention has two parts: the first is a values clarification exercise, and the second part is a CPR video decision aid that explains the risks and benefits of CPR as well as the reasons a patient may choose to receive CPR or not. From previous research it is known that many hospitalized patients have prescribed orders for CPR despite expressing a preference not to have CPR when asked. Furthermore patients often have expressed values that are not concordant with their expressed wishes regarding resuscitation. Therefore it is hypothesized that fewer patients in the intervention group will have a documented order for CPR and they will have greater satisfaction with decision making about CPR than patients in the control group.

We will conduct sensitivity analyses to investigate whether the intervention is more effective among patients who remain in hospital longer after enrollment. We will measure the intervention effect among patients who remained in hospital for fewer than three days after enrollment, among patients who were in hospital for 3-7 days after enrollment, and among patients who remained in hospital for longer than 7 days post-enrollment.


Recruitment information / eligibility

Status Completed
Enrollment 200
Est. completion date October 22, 2018
Est. primary completion date October 22, 2018
Accepts healthy volunteers No
Gender All
Age group 55 Years and older
Eligibility Inclusion Criteria:

1. Eligible to receive CPR

2. Satisfying at least one of the following criteria groups

1. 55 years of age or older with one or more of the following diagnoses:

- Chronic obstructive lung disease (2 of the 3 of: baseline PaCO2 of > 45 torr, cor pulmonale; respiratory failure episode within the preceding year; forced expiratory volume in 1 sec <0.5 L)

- Congestive heart failure (New York Heart Association class IV symptoms and left ventricular ejection fraction < 25%)

- Cirrhosis (confirmed by imaging studies or documentation of esophageal varices and one of three conditions; hepatic coma, child's class C liver disease, or child's class B liver disease with gastrointestinal bleeding)

- Cancer (metastatic cancer or stage IV lymphoma)

- End-stage dementia (inability to perform all ADLs, mutism or minimal verbal output secondary to dementia, bed-bound state prior to acute illness).

2. 80 years of age or older and admitted to hospital from the community for an acute medical or surgical condition.

3. If none of the above criteria are met, any patient whose death within the next 6 months would not surprise any member of their care team.

4. At least 55 years old and predicted risk of death in the next 12 months of >=10% as calculated with the HOMR Now! Score

Exclusion Criteria:

- Patients or SDMs who do not speak English.

- Patients or SDMs who do not provide informed consent.

Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
Decision Support
A two-part intervention to help patients make better decisions about CPR

Locations

Country Name City State
Canada Ottawa Hospital Civic Campus Ottawa Ontario
Canada The Ottawa Hospital General Campus Ottawa Ontario

Sponsors (3)

Lead Sponsor Collaborator
Ottawa Hospital Research Institute Canadian Frailty Network, The Ottawa Hospital Academic Medical Association

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Primary CPR Orders The proportion of patients with an order for CPR in the medical record 14 days post enrollment
Secondary Patient/Substitute Decision Maker (SDM) satisfaction with decision-making Decision-making domain of the Canadian Health Care Evaluation Project (CANHELP) questionnaire Immediately after intervention, or enrollment for control group
Secondary Decisional Conflict Measured using a modified version of the Decisional Conflict Scale Immediately after intervention, or enrollment for control group
Secondary Health Resource Usage Case costing system at the Ottawa Hospital data warehouse used to measure total cost of hospital care for patients (direct and indirect) From enrolment to 1 year after enrollment.
Secondary Number of documented goals of care conversations Count of documented goals of care conversations, defined as "a conversation that addressed at least one of the following domains: patient values and goals; prognosis or illness understanding; end-of-life care planning; or code status (that is, whether or not a patient has requested resuscitation in the event of a Code Blue) or desire for other life-sustaining treatments or procedures." (Lakin et al. Health Affairs 36, no.7 (2017):1258-1264). We will report the presence or absence of any goals of care conversation, as well as the mean number of conversations in each group. Between study enrollment and up to 14 days post enrollment
Secondary Quality of documented goals of care conversations Mean quality score for the first instance of a goals of care conversation following study enrollment. Quality assessed using the scale developed for Lakin et al. 2017. This scale has a maximum score of 17 and a minimum score of 1. Between study enrollment and up to 14 days post enrollment
Secondary SDM Self-efficacy For substitute decision-makers who participate, their confidence to make medical decisions on behalf of their loved will be measured using a 5-question questionnaire. The questionnaire asks SDMs to rate their knowledge and confidence about different aspects of decision-making, on a scale from 0 (not confident at all) to 4 (very confident). SDM self-efficacy will be calculated as the mean score among the 5 questions. Immediately after intervention, or enrollment for control group
Secondary Number of emergency department visits Count of presentations to emergency department In the year following index admission
Secondary Number of participants with in-hospital mortality Participants will contribute to this measure if they die while admitted to hospital In the year following index admission
Secondary Discharge Disposition Patient destination on discharge from index admission (home, home with support, rehabilitation, long-term care, etc). End of index admission
Secondary Number of hospital admissions Count of admissions to hospital In the year following index admission
Secondary Number of hospital days Count of days admitted to hospital In the year following index admission
Secondary Number of ICU days Count of days admitted to an intensive care unit In the year following index admission