Risk Identification of Long-term Complications

Severe COVID-19 Clinical Trial

Official title:

Risk Identification of Long-term Complications in the Recover Patients With Severe COVID-19

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT06235866
• Other study ID #: 20230922
• Status: Enrolling by invitation
• Start date: February 1, 2023
• Est. completion date: November 1, 2025

Study information

• Verified date: May 2024
• Source: Wuhan Central Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigators retrospectively analyze the clinical characteristics of severe COVID-19 in our hospital, and then establish a prediction model for long-term complications in patients with severe COVID-19, and strengthen follow-up to improve the prognosis of patients.

Description:

At present, there is a lack of prediction models for the long-term complications of severe COVID-19. Therefore, the investigators used the hospital big data platform to retrospectively analyze the clinical characteristics of severe COVID-19 in our hospital, and conducted cohort follow-up of the changes in lung function including FEV1, FVC，FEV1% and DLCO, etc and and high-resolution CT of patients after discharge. COX model and other statistical methods were used to establish a prediction model for long-term complications of severe COVID-19, and early identification and intervention, strengthen follow-up, and improve the prognosis of patients.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 500
• Est. completion date: November 1, 2025
• Est. primary completion date: September 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

The patient met the diagnostic criteria for severe COVID-19

Exclusion Criteria:

• Pregnant women Patients who died of COVID-19 Patients younger than 18 years of age without pulmonary CT

Related Conditions & MeSH terms

• COVID-19
• Severe COVID-19

Intervention

Other:
• Pulmonary rehabilitation
According to the pulmonary rehabilitation guidelines, patients with severe COVID-19 were given regular rehabilitation treatment, including breathing exercises and physical rehabilitation exercises.

Locations

Country	Name	City	State
China	Follow-up of patients with severe COVID-19	Wuhan

Sponsors (1)

Lead Sponsor	Collaborator
Wuhan Central Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lung function	Pulmonary function indicators improved gradually	1 year
Primary	Imaging of the lung	The residual lesions in the lung were gradually absorbed	1 year