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Clinical Trial Summary

Adults who do not have major health, kidney, gastrointestinal disease will be randomized to receive oral mitoquinone/mitoquinol mesylate (Mito-MES) versus placebo to prevent the development and progression of COVID-19 after high-risk exposure to a person with confirmed SARS-CoV-2 infection.


Clinical Trial Description

The overall goal of the study is to determine the efficacy of the treatment with mito-MES 20 mg daily versus placebo for 14 days to prevent confirmed SARS-CoV-2 infection in high-risk close contacts of confirmed COVID-19 cases. Primary measure will be confirmed COVID-19 infection based on a diagnostic test within 14 days after exposure. Secondary measures of efficacy will be symptomatic viral infection, hospitalization, respiratory failure requiring ventilatory support attributable to COVID-19 disease, mortality. The secondary objective is to determine the safety of mito-MES for 14 days as post-exposure prophylaxis against SARS-CoV-2 in healthy adults. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05886816
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact Theodoros Kelesidis, MD, PHD, Msc
Phone 214-648-3486
Email Theodoros.Kelesidis@UTSouthwestern.edu
Status Recruiting
Phase Phase 2
Start date March 1, 2024
Completion date July 31, 2025

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