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NCT05836428 Clinical Trial

Biomarker Analysis in Post-COVID Patients

Post-COVID-19 Syndrome Clinical Trial

Official title:
Biomarker Analysis in COVID and Post-COVID Patients

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05836428
Other study ID # 2
Secondary ID
Status Completed
Phase
First received
Last updated
Start date August 1, 2020
Est. completion date April 26, 2023

Study information
Verified date April 2023
Source University Hospital, Bonn
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Headache is one of the most common neurological manifestations of COVID-19. However, it is unclear whether chronic headache after the initial diagnosis, is associated with ongoing damage of the central nervous system. We investigate cpost-COVID-19 patients with persistent headache lasting longer than 3 weeks, to hospitalized acute COVID-19 patients with neurological symptoms and to other non-COVID-19 disease-controls. Readout are neurologial and glial biomarkers in CSF.

Description:

Measurements of neuronal and glial markers in CSF were performed on a SIMOA analyzer (Quanterix) using the Neurology 4-Plex A (Nf-L, Tau, GFAP, UCH-L1) kit.

Recruitment information / eligibility
Status Completed
Enrollment 48
Est. completion date April 26, 2023
Est. primary completion date April 26, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Diagnosis of COVID, Parkinson's disease, primary headache, Multiples Sclerosis, facial paralysis - Persistent post-COVID-19 headache after 3 months of infection - Post COVID-patients without persistent headache - must be able to perform lumbar puncture Exclusion criteria - unknown history of COVID infection - lumbar puncture not possible

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• no intervention
no intervention

Locations
Country Name City State
Germany Laura de Boni Bonn

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Bonn

Country where clinical trial is conducted

Germany, 

Outcome
Type Measure Description Time frame Safety issue
Primary Biomarker analysis in CSF Levels of Nf-L, Tau, GFAP, UCH-L1 in CSF after 3 months of initial infection
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