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NCT05474300 Clinical Trial

Effect of Slope Time in PCV Mode on Mechanical Power Calculation and Oxygenation in Covid-19 ARDS Patients.

COVID-19 Pneumonia Clinical Trial

Official title:
Retrospective Evaluation of the Effect of Slope Time in PCV Mode on Mechanical Power Calculation and Oxygenation in Covid-19 ARDS Patients.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05474300
Other study ID # 2022/209
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 6, 2022
Est. completion date August 30, 2022

Study information
Verified date August 2022
Source Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Contact sinan asar, M.D
Phone +905442659844
Email sinanasaras@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The investigators are planning to investigate the effect of each 5% slope time change on mechanical power and SPO2 of the patients with Covid 19 ARDS diagnosis which are on mechanical ventilation PCV mode support.

Description:

In this study, with inspiration/expiration 1:2 and 1:1 time ratios in pressure controlled ventilation mode with different slope times mechanical power will be calculated in covid ARDS patients. In this way, the effect of every 5% slope time change in PCV on mechanical power and SPO2 will be investigated.

Recruitment information / eligibility
Status Recruiting
Enrollment 40
Est. completion date August 30, 2022
Est. primary completion date August 6, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - adult patients with Covid-19 Acute Respiratory Distress Syndrome (ARDS) diagnosis - intubated Covid-19 ARDS patients - Covid-19 ARDS patients on mechanical ventilator support Exclusion Criteria: - heart failure disease - Chronic Obstructive Pulmonary Disease (COPD) - hemodynamically unstable patients - pregnancy

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• mechanical ventilation
Pressure controlled ventilation mode on mechanical ventilation

Locations
Country Name City State
Turkey Bakirköy Dr sadi konuk Education hospital Istanbul

Sponsors (1)
Lead Sponsor Collaborator
Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Becher T, van der Staay M. Calculation of mechanical power for pressure-controlled ventilation: author's reply. Intensive Care Med. 2019 Oct;45(10):1498-1499. doi: 10.1007/s00134-019-05742-7. Epub 2019 Aug 20. — View Citation

Trinkle CA, Broaddus RN, Sturgill JL, Waters CM, Morris PE. Simple, accurate calculation of mechanical power in pressure controlled ventilation (PCV). Intensive Care Med Exp. 2022 May 30;10(1):22. doi: 10.1186/s40635-022-00448-5. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary mechanical power Mechanical power calculated by Becher et al. comprehensive formula (MPpcv(slope)) and Trinkle, Christine A et al lineer model mechanical power formula (MPLM). 100 minutes
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