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NCT05408481 Clinical Trial

Relation Between COVID-19 Pts and Hyponatremia in Adreno Ortical Insufficient Patients.

COVID-19 Clinical Trial

Official title:
Hyponatremia in COVID-19 Patients With Adrenal Insufficiency and Its Relation to Mortality and Survival Scores.

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05408481
Other study ID # COVID-19 hyponatremia
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date June 2022
Est. completion date March 2023

Study information
Verified date June 2022
Source Assiut University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Hyponatremia in COVID-19 patients with adrenal insufficiency

Description:

Hyponatremia is the most prevalent hydroelectrolytic disorder in clinical practice, and is linked to higher rates of morbidity and mortality. 1, 2.Sodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with COVID-19 . and it is associated with a higher risk of morbidity, mortality, and disability. Acute hyponatremia causes serious brain swelling that can lead to permanent disability or death. Chronic hyponatremia causes attention deficit, gait instability, and osteoporosis, Mechanisms of hyponatremia in coronavirus disease 2019 (COVID-19) patients. Osmotic syndrome of inappropriate antidiuretic hormone release (SIADH) as a major mechanism. Also hypovolemic hyponatremia that may have been common in COVID-19 patients since nausea, vomiting, diarrhea.we predict critical illness-related corticosteroid insufficiency (CIRCI) play a role in hyponatremia in COVID-19 , high percentage of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection in the study were treated with vasopressors (2). Angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2 serine protease were colocalized in adrenocortical cells in the zona fasciculata and zona reticularis (2). plasma cortisol concentrations will be collected in critically ill patients with COVID-19 (2). The cortisol levels of critically ill patients with COVID-19 were low(2).We aimed to identify the previlence and mortality rate of hyponatremia in covid 19 patient with adrenal insufficiency . Our studies will present in Assiut hospital university on patients in isolation ward from October 2021 to October 2022.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 50
Est. completion date March 2023
Est. primary completion date December 2022
Accepts healthy volunteers
Gender All
Age group 19 Years to 80 Years
Eligibility Inclusion Criteria: - 1-Suspected COVID-19 patients come to isolation hospital in Assuit. 2-Hyponatremia. 3- Adrenal insufficiency Exclusion Criteria: - Non-cooperative patients

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Serum cortisol level
Biochemical test

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

Outcome
Type Measure Description Time frame Safety issue
Primary The effect of hyponatremia on mortality of COVID-19 patient with adrenal insufficiency Na level will be measured in COVID-19 patients with adrenal insufficiency Baseline
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