Coronavirus Disease 2019 (COVID-19) Clinical Trial
Official title:
Evaluation of Silver Nanoparticles as an Oropharyngeal Product (Mouthwash) and Nasal Hygiene, by Health Personnel Working at the Tijuana General Hospital Exposed to Patients Diagnosed With Atypical Pneumonia Caused by SARS-CoV-2
In this research, silver nanoparticles (AgNPs) were tested in vitro and shown to have an inhibitory effect on SARS-CoV-2 infection in cultured cells. Subsequently, the investigators assessed the effects of mouthwash and nose rinse with ARGOVIT® silver nanoparticles (AgNPs), in the prevention of SARS-CoV-2 contagion in health workers consider as high-risk group of acquiring the infection in the General Tijuana Hospital, Mexico, a hospital for the exclusive recruitment of patients diagnosed with COVID-19.
SARS-CoV-2 infection in hospital areas is of a particular concern, since the close interaction between health care personnel and patients diagnosed with COVID-19, which allows virus to be easily spread between them and subsequently to their families and communities. Preventing SARS-CoV-2 infection among healthcare personnel is essential to reduce the frequency of infections and outbreaks during the pandemic. In a first step, silver nanoparticles (AgNPs) were tested in vitro to determine an inhibitory effect on SARS-CoV-2 infection in cultured cells. Subsequently, the investigators assess the effects of mouthwash and nose rinse with ARGOVIT® silver nanoparticles (AgNPs), in the prevention of SARS-CoV-2 contagion in health workers consider as high-risk group of acquiring the infection in the General Tijuana Hospital, Mexico, a hospital for the exclusive recruitment of patients diagnosed with COVID-19. The investigators present a prospective randomized study of 231 participants that was carried out for 9 weeks (during the declaration of a pandemic). The "experimental" group was instructed to do mouthwash and nose rinse with the AgNPs solution; the "control" group was instructed to do mouthwashes and nose rinse in a conventional way. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04516564 -
A Study of AK119 (Anti-CD73 Antibody), a Treatment for COVID-19, in Healthy Subjects
|
Phase 1 | |
| Not yet recruiting |
NCT04395170 -
Convalescent Plasma (PC) and Human Intravenous Anti-COVID-19 Immunoglobulin (IV Anti COVID-19 IgG) in Patients Hospitalized for COVID-19.
|
Phase 2/Phase 3 | |
| Withdrawn |
NCT04519424 -
CSL324 in COVID-19
|
Phase 2 | |
| Completed |
NCT05437289 -
A Study to Evaluate the Safety and Tolerability of AZD7442 in Healthy Chinese Adults
|
Phase 1 | |
| Completed |
NCT05594147 -
An Observational Study, Called ROCURS, to Learn About COVID-19 Related Outcomes in People With Cancer Who Are Treated With Tyrosine Kinase Inhibitors (TKIs) Including Regorafenib or Sorafenib
|
||
| Withdrawn |
NCT04848467 -
COVID-19: A Trial Studying the SARS-CoV-2 mRNA Vaccine CVnCoV to Learn About the Immune Response, the Safety, and the Degree of Typical Vaccination Reactions When CVnCoV is Given at the Same Time as a Flu Vaccine Compared to When the Vaccines Are Separately Given in Adults 60 Years of Age and Older
|
Phase 3 | |
| Completed |
NCT04588363 -
COVID-19: Pediatric Research Immune Network on SARS-CoV-2 and MIS-C
|
||
| Terminated |
NCT04877743 -
Non-Interventional Enhanced Active Surveillance Study of Adults Vaccinated With AZD1222
|
||
| Completed |
NCT04742725 -
A Study to Evaluate the Efficacy and Safety of Prothione™ Capsules for Mild to Moderate Coronavirus Disease 2019 (COVID-19)
|
Phase 2 | |
| Completed |
NCT04545047 -
Observational Study of Convalescent Plasma for Treatment of Veterans With COVID-19
|
||
| Completed |
NCT04375761 -
COVID-19: Human Epidemiology and Response to SARS-CoV-2
|
||
| Completed |
NCT04378777 -
Immunophenotyping Assessment in a COVID-19 Cohort
|
||
| Completed |
NCT04327206 -
BCG Vaccination to Protect Healthcare Workers Against COVID-19
|
Phase 3 | |
| Terminated |
NCT05375760 -
A Randomized, Open-label, Dose-ranging Study in Adults and Pediatric Individuals ≥ 12 Years of Age to Assess the Safety, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of AZD7442, for Pre-exposure Prophylaxis of COVID-19
|
Phase 2 | |
| Completed |
NCT04344977 -
Collection of Anti-SARS-CoV-2 Immune Plasma
|
||
| Terminated |
NCT04389840 -
Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure
|
Phase 2/Phase 3 | |
| Withdrawn |
NCT04425733 -
MK-5475 in Participants With Hypoxemia Due to COVID-19 Pneumonia (MK-5475-009)
|
Phase 1 | |
| Not yet recruiting |
NCT04438837 -
Hydroxychloroquine Post-Exposure Prophylaxis for Coronavirus Disease (COVID-19) Among Health-Care Workers
|
N/A | |
| Completed |
NCT04409509 -
Treatment With CSL312 in Adults With Coronavirus Disease 2019 (COVID-19)
|
Phase 2 | |
| Completed |
NCT04275245 -
Clinical Study of Anti-CD147 Humanized Meplazumab for Injection to Treat With 2019-nCoV Pneumonia
|
Phase 1/Phase 2 |