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NCT04497649 Clinical Trial

Sofosbuvir Containing Regimens in Treatment of COVID 19 Patients

Covid19 Clinical Trial

Official title:
Sofosbuvir Containing Regimens in Treatment of COVID 19 Patients: A Randomized Controlled Trial.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04497649
Other study ID # Tanta sofosbuvir covid
Secondary ID
Status Recruiting
Phase Phase 2/Phase 3
First received
Last updated
Start date July 1, 2020
Est. completion date April 10, 2021

Study information
Verified date December 2020
Source Tanta University
Contact Sherief Abd-Elsalam, ass. prof.
Phone 00201147773440
Email sheriefabdelsalam@yahoo.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

efficacy and safety of Sofosbuvir containing regimens in treatment of COVID-19 Egyptian patients,

Description:

The study aims to assess Sofosbuvir containing regimens in treatment of COVID-19 Egyptian patients,

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date April 10, 2021
Est. primary completion date April 1, 2021
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - COVID 19 positive patients Exclusion Criteria: - COVID-19 patients with critical manifestations. - Sepsis. - Acute respiratory distress syndrome (ARDS). - Decompensated liver disease (Child-Pugh class B or C disease). - Chronic renal impairment. - Patients with blood diseases (severe anemia, thalassemia, ITP, leukemia ….). - Ischemic heart disease within the last 6 months. - Chronic pulmonary disease. - Malignancy. - Pregnancy or breastfeeding. - Hypersensitivity to sofosbuvir or ribavirin. - Patients with organ transplant. - Unwilling to participate in our study

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Sofosbuvir
Sofosbuvir once daily
• Daclatasvir
daclatasuvir once daily

Locations
Country Name City State
Egypt Cairo and Tanta Universitities Tanta

Sponsors (1)
Lead Sponsor Collaborator
Tanta University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of patients with improvement or mortality The number of patients with improvement or mortality 1 month
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