COVID Clinical Trial
— SIZI-COVID-PKOfficial title:
Sub-cutaneous Ivermectin in Combination With and Without Oral Zinc: a Placebo Randomized Control Trial on Mild to Moderate COVID-19 Patients
To measure the effect of Ivermectin (sub-cutaneous) with or without zinc in treating the COVID-19 patients to clear viral load of SARS-CoV-2 along with reduction in severity of symptoms and length of hospitalization of patients with COVID-19.
Status | Recruiting |
Enrollment | 180 |
Est. completion date | October 30, 2021 |
Est. primary completion date | August 15, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Nasopharyngeal RT-PCR positive SARS-CoV-2 patient with mild to moderate disease - Age 18 and above - BMI 18-28 kg/m Exclusion Criteria: - Allergy to any drug - Co-morbidities: any pre-existing cardiac disease, pulmonary disease - Arrhythmias - Pregnancy - RT-PCR performed >3 days prior to enrollment |
Country | Name | City | State |
---|---|---|---|
Pakistan | Ali Clinic | Lahore | MA |
Pakistan | Shaikh Zayed Hospital | Lahore | Punjab |
Lead Sponsor | Collaborator |
---|---|
Sohaib Ashraf |
Pakistan,
Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 2020 Jun;178:104787. doi: 10.1016/j.antiviral.2020.104787. Epub 2020 Apr 3. — View Citation
Patrì A, Fabbrocini G. Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment? J Am Acad Dermatol. 2020 Jun;82(6):e221. doi: 10.1016/j.jaad.2020.04.017. Epub 2020 Apr 10. — View Citation
Simsek Yavuz S, Ünal S. Antiviral treatment of COVID-19. Turk J Med Sci. 2020 Apr 21;50(SI-1):611-619. doi: 10.3906/sag-2004-145. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | qRT-PCR | time needed to turn positive COVID-19 PCR to negative | 14 days | |
Primary | Time taken for alleviation of symptoms | time needed to turn off symptoms | upto 14 days | |
Primary | Severity of symptoms | time needed of symptom serverity | upto 14 days | |
Secondary | Severity of symptoms | time needed to make patients clinically better | 14 days | |
Secondary | Morality | death rate | 30 days |
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