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Convalescent Plasma as Treatment for Acute Coronavirus Disease (COVID-19)

COVID-19 Clinical Trial

Official title:
Plasma From Individuals Who Have Recovered From Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection as Treatment for Acute COVID-19 Disease

Clinical Trial Summary

There is currently no effective treatment for COVID-19 except best supportive care. The aim is assess the safety, tolerability and efficacy of convalescent plasma for treatment of patients with varying degrees of COVID-19 illness.

Clinical Trial Description

Convalescent plasma has been shown to be safe and effective for treatment of several diseases. Preliminary data indicates that it is safe and effective for treatment of COVID-19. However, data is limited to small studies and case series on severely ill patients. The proposed study assesses the safety and efficacy earlier in the course of illness, in slightly less severe patients with the possibility of detecting less severe adverse events and the potential for early treatment to hinder the development of severe disease. Plasma is collected from consenting donors who have recovered from SARS-CoV-2. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04390178
Study type Interventional
Source Karolinska University Hospital
Contact
Status Completed
Phase Phase 1/Phase 2
Start date April 10, 2020
Completion date December 31, 2020
View Details
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