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NCT04368143 Clinical Trial

COVID-19 Immune Repertoire Sequencing

COVID Clinical Trial

— IMSEQ  

Official title:
COVID-19 Immune Repertoire Sequencing

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04368143
Other study ID # IMSEQ
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 1, 2020
Est. completion date December 2, 2021

Study information
Verified date September 2023
Source Institute of Tropical Medicine, Belgium
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

This concerns a single-center prospective interventional cohort study. Laboratory-confirmed COVID-19 patients will be asked to donate blood at at least two different timepoints. This will allow us to investigate T and B cell evolutions during the course of infection and recovery. The expected duration of the study is four months or the total duration of the SARS-CoV-2 circulation in Belgium (whichever is shortest).

Recruitment information / eligibility
Status Completed
Enrollment 84
Est. completion date December 2, 2021
Est. primary completion date December 2, 2021
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - laboratory confirmed COVID-19 acute infection - be older than 18 years of age - be hospitalized at the UZA - willing and able to provide written informed consent by the participant or its legal representative (for instance in case of medical incapacitation) Exclusion Criteria: - younger than 18 years old - Ambulatory patients

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Belgium Universitairy hospital of Antwerp Antwerp

Sponsors (2)
Lead Sponsor Collaborator
Institute of Tropical Medicine, Belgium University Hospital, Antwerp

Country where clinical trial is conducted

Belgium, 

Outcome
Type Measure Description Time frame Safety issue
Primary provide proof-of-concept that (longitudinal) B cell repertoire mining allows identification of emerging virus specific B cell receptor variable regions. 4 months
Secondary study evolutions in B and T cell repertoires to understand COVID-19 specific immune responses fundamentally. every 7 days during hospitalization a bloodsample is taken
Secondary clinical and epidemiological description of UZA hospitalized COVID-19 patients at hospitalization
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