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Clinical Trial Summary

The Austrian Coronavirus Adaptive Clinical Trial (ACOVACT) is a randomized, controlled, multicenter, open-label basket trial that aims to compare various antiviral treatments for COVID-19. Moreover three substudies have been integrated. Currently, patients will be randomized to receive (hydroxy-)chloroquine (Treatment stopped after reports of safety issues), lopinavir/ritonavir, remdesivir or standard of care. Moreover, these patients are eligible for substudy A (randomized to rivaroxaban 5mg 1-0-1 vs. standard of care), substudy B (renin-angiotensin (RAS) blockade vs. no RAS blockade for patients with blood pressure >120/80mmHg), and substudy C (asunercept vs standard of care, pentglobin vs. standard of care for patients with respiratory deterioration and high inflammatory biomarkers). Endpoints were chosen based on the master protocol published by the World Health Organisation and include a 7-point scale of clinical performance, mortality, oxygen requirement (both dose and type), duration of hospitalization, viral load and safety.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04351724
Study type Interventional
Source Medical University of Vienna
Contact Bernd Jilma, MD
Phone +4314040029810
Email klin-pharmakologie@meduniwien.ac.at
Status Recruiting
Phase Phase 2/Phase 3
Start date April 16, 2020
Completion date March 31, 2022

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