COVID Clinical Trial
— ChilblainCOVIDOfficial title:
Assessment of Skin Manifestations Occuring During Covid-19 Infection With a Special Focus on Chilbains
Some patients infected by covid-19 develop skin manifestations. These manifestations are still not well known and there pathophysiology remain unclear. Among them, acral manifestation resembling to chilblains appears frequent and quite specific. The aim of this project is to better characterize the cutaneous manifestations occurring during Covid-19 infection with a special focus on chilblains. These acral manifestation could be due to a direct viral effect, but also to microthrombosis or vascularitis. Understanding the pathomechanisms involved could provide interesting clue for understanding not only the skin manifestations but also some of the other systemic symptoms associated to covid-19 infection. This study plan to characterize these acral manifestations by analyzing the clinical and dermoscopic patterns and to correlate them with the non-invasive vascular explorations but also immune and coagulopathy explorations that are done in the CHU of Nice in covid-19 patients.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | April 30, 2021 |
Est. primary completion date | April 30, 2021 |
Accepts healthy volunteers | |
Gender | All |
Age group | N/A to 90 Years |
Eligibility | Inclusion Criteria: - All patients with proven covid infection (using PCR, serum antibody or lung TDM) and presenting at least one cutaneous lesions that occurred during the infection. |
Country | Name | City | State |
---|---|---|---|
France | CHU de Nice | Nice |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire de Nice |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinical skin manifestations | Type and description of the skin manifestations with a special focus on patients with chilblains | 3 months | |
Secondary | Histology and biological data | Data on Histology (HE staining and immunofluorescence) and on biology (blood cells counts, CRP and immune profile) will be collected in covid patient with skin manifestation | 3 months | |
Secondary | Non invasive vascular examination | Vascular examination will be performed by Capillaroscopy, laser-doppler or lung TDM if clinically required | 3 months |
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