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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04344119
Other study ID # 20dermatocovid01
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 9, 2020
Est. completion date April 30, 2021

Study information

Verified date April 2020
Source Centre Hospitalier Universitaire de Nice
Contact Cynthia CAILLON
Phone +33492034011
Email caillon.c@chu-nice.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Some patients infected by covid-19 develop skin manifestations. These manifestations are still not well known and there pathophysiology remain unclear. Among them, acral manifestation resembling to chilblains appears frequent and quite specific. The aim of this project is to better characterize the cutaneous manifestations occurring during Covid-19 infection with a special focus on chilblains. These acral manifestation could be due to a direct viral effect, but also to microthrombosis or vascularitis. Understanding the pathomechanisms involved could provide interesting clue for understanding not only the skin manifestations but also some of the other systemic symptoms associated to covid-19 infection. This study plan to characterize these acral manifestations by analyzing the clinical and dermoscopic patterns and to correlate them with the non-invasive vascular explorations but also immune and coagulopathy explorations that are done in the CHU of Nice in covid-19 patients.


Recruitment information / eligibility

Status Recruiting
Enrollment 30
Est. completion date April 30, 2021
Est. primary completion date April 30, 2021
Accepts healthy volunteers
Gender All
Age group N/A to 90 Years
Eligibility Inclusion Criteria: - All patients with proven covid infection (using PCR, serum antibody or lung TDM) and presenting at least one cutaneous lesions that occurred during the infection.

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
France CHU de Nice Nice

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Universitaire de Nice

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Clinical skin manifestations Type and description of the skin manifestations with a special focus on patients with chilblains 3 months
Secondary Histology and biological data Data on Histology (HE staining and immunofluorescence) and on biology (blood cells counts, CRP and immune profile) will be collected in covid patient with skin manifestation 3 months
Secondary Non invasive vascular examination Vascular examination will be performed by Capillaroscopy, laser-doppler or lung TDM if clinically required 3 months
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