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Efficacy of Pentoxifylline as Add on Therapy in COVID19 Patients

COVID Clinical Trial

Official title:
Efficacy of Pentoxifylline as Add on Therapy in COVID19 Patients

Clinical Trial Summary

With potential antiviral effects on severe acute respiratory syndrome (SARS) and as a methyl-xanthine derived inhibitor of phosphodiesterase-4, pentoxifylline basically functions as a hemorrheologic agent for a better circulation and oxygenation and exerts unique effects on immune modulation, inflammation and oxidative stress. As the main regulator of cAMP metabolism, posphodiesterase-4 plays a key role in proinflammatory and immune cells. Pentoxifylline plays its anti-inflammatory role by reducing the production of proinflammatory cytokines such as TNF-a, IL-1 and IL-6. Given its unique impacts on immune modulation, homeostasis and fibrinolysis and its supportive effects on oxidative stress and organ failure, pentoxifylline can constitute a multipurpose and generally-safe adjuvant therapy for COVID-19 patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04433988
Study type Interventional
Source Sadat City University
Contact
Status Withdrawn
Phase Phase 1/Phase 2
Start date November 13, 2022
Completion date December 30, 2022
View Details
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