COVID-19 Infection Clinical Trial
Official title:
Study of Hemostasis in Case of Severe COVID-19
The COVID-19 outbreak has led to a significant increase in the number of patients admitted to
intensive care for respiratory distress. Early data indicate a particularly high risk of
thrombotic risk to viral lung disease, particularly in the most severe patients, with a
particularly high incidence of pulmonary embolism. Catheter thrombosis and extra-renal
purification filters are also abnormally common. These thrombotic complications could
contribute to the mortality observed in this pathology. The introduction of early curative
anticoagulation in the most severe patients has just been proposed by the perioperative
hemostasis interest group
Biologically, a significant proportion of patients hospitalized in intensive care have a
marked biological inflammatory syndrome, associated with signs of activation of clotting (a
frank increase in D-dimers). The presence of circulating anticoagulants is common.
Interestingly, thrombocytosis, normally observed in such inflammatory syndromes, is absent.
In this context, it seems legitimate to explore these patients from a hemostasis perspective
to identify the factors that cause this thrombotic over-risk, in order to minimize the
occurrence of these complications.
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