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NCT ID: NCT02855944 Completed - Ovarian Cancer Clinical Trials

ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients

Start date: March 1, 2017
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine how patients with ovarian, fallopian tube, and primary peritoneal cancer will best respond to treatment with rucaparib versus chemotherapy.

NCT ID: NCT02849626 Completed - Clinical trials for Partial-Onset or Primary Generalized Tonic-Clonic Seizures

Perampanel as Adjunctive Therapy in Pediatrics With Partial Onset Seizures or Primary Generalized Tonic Clonic Seizures

Start date: November 16, 2016
Phase: Phase 3
Study type: Interventional

This is an open-label, multicenter study with an Extension Phase to evaluate the safety and tolerability of perampanel oral suspension when administered as an adjunctive therapy in children (ages 4 to less than [<] 12 years) with inadequately controlled partial onset seizures (POS) or primary generalized tonic clonic (PGTC) seizures.

NCT ID: NCT02848443 Completed - Clinical trials for Metastatic Colorectal Cancer

Study of S 95005 in Combination With Oxaliplatin in Metastatic Colorectal Cancer

Start date: May 2016
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to assess the safety and tolerability and to determine the recommended phase 2 dose of S 95005 given in combination with oxaliplatin in patients with metastatic colorectal cancer.

NCT ID: NCT02847728 Completed - Lung Cancer Clinical Trials

Pattern of Use and Safety/Effectiveness of Nivolumab in Routine Oncology Practice

Start date: July 28, 2016
Phase:
Study type: Observational

This is an observational, multicenter study in participants treated with nivolumab for the approved indications of melanoma and Lung cancer in Australia, the EU, Switzerland, the United Kingdom (UK), and the United States (US). The targeted countries in the EU for study participation include Austria, Belgium, Czech Republic, France, Germany, Hungary, Italy, Poland, and Spain. Study objectives are to assess the safety experience, survival, adverse event management, and outcomes of adverse events associated with nivolumab in routine oncology care facilities.

NCT ID: NCT02839200 Completed - Insomnia Disorder Clinical Trials

Efficacy and Safety of ACT-541468 in Adult Subjects With Insomnia Disorder

Start date: October 4, 2016
Phase: Phase 2
Study type: Interventional

This study evaluates the dose response of ACT-541468 on the change of WASO from baseline to Days 1 and 2, assessed by PSG.

NCT ID: NCT02835456 Completed - Clinical trials for Catheter Associated Urinary Tract Infections

Does Micropattern on Urinary Catheter Surface Reduce Urinary Tract Infections?

SHARKLET
Start date: August 2016
Phase: Phase 1
Study type: Interventional

The aim of this study is to determine if the Sharklet catheter, with its unique surface micropattern, reduces infections in participants, when compared to a standard silicone catheter.

NCT ID: NCT02833389 Completed - Clinical trials for Neuropathic Diabetic Foot Ulcers

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of UTTR1147A in Participants With Neuropathic Non-Healing Diabetic Foot Ulcers

Start date: November 14, 2016
Phase: Phase 1
Study type: Interventional

This trial will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of repeat dosing of UTTR1147A in participants with neuropathic diabetic foot ulcers that do not respond adequately to standard wound care. Participants across multiple sites will be assigned to one of five cohorts (Cohort A, B, C, D, and E) based on the eligibility criteria and randomized to receive subcutaneous (SC) injections of either UTTR1147A or placebo over 12 weeks in addition to standard wound care.

NCT ID: NCT02831855 Completed - Clinical trials for Rheumatoid Arthritis

Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid Arthritis

Start date: September 1, 2016
Phase: Phase 4
Study type: Interventional

This study is designed to evaluate the efficacy and safety of tofacitinib modified release formulation (11mg QD) versus tofacitinib modified release formulation plus continued methotrexate treatment in subjects with moderate to severe rheumatoid arthritis who are insufficiently responding to their stable dose of methotrexate treatment.

NCT ID: NCT02828930 Completed - Solid Tumors Clinical Trials

A Study to Determine the Excretion Balance, Pharmacokinetics, Metabolism and Absolute Oral Bioavailability of a Single Oral Dose of [14C]-Labeled Idasanutlin and an Intravenous Tracer Dose of [13C]-Labeled Idasanutlin in a Single Cohort of Participants With Solid Tumors (Malignancies)

Start date: September 8, 2016
Phase: Phase 1
Study type: Interventional

The purpose of this single-center, open-label, non-randomized study is to assess the excretion balance, pharmacokinetics, metabolism and absolute oral bioavailability of [14C]-labeled idasanutlin administered orally and [13C]-labeled idasanutlin administered intravenously in a single cohort of eligible participants. Participants will be screened for participation in this study within 21 days of receiving the first dose of study drug on Day 1. Treatment period will continue up to Day 28 after which participants will enter 28 day follow-up or the optional treatment extension of idasanutlin, depending on safety parameters and as per opinion of the Investigator.

NCT ID: NCT02826603 Completed - Plaque Psoriasis Clinical Trials

Study of Secukinumab Compared to Ustekinumab in Subjects With Plaque Psoriasis

CLARITY
Start date: June 22, 2016
Phase: Phase 3
Study type: Interventional

Demonstrate superiority of secukinumab over ustekinumab in treatment of moderate to severe plaque psoriasis.