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Clinical Trial Summary

To investigate the value of blood eosinophils, FeNO and total IgE in predicting the response to inhaled corticosteroid in patients with chronic cough.


Clinical Trial Description

Chronic cough is a frequent complaint in respiratory specialists clinic. CVA, UACS, EB, GERC and AC are common causes of chronic cough, among whom, CVA, EB and AC can be classified as corticosteroid responsive cough. To recognize the eosinophilic airway inflammation and assess the response of inhaled corticosteroid, induced sputum analysis is the most widely used examination but not all the subjects can provide an suitable sample of sputum for measurements and it's time-consuming. Recently, blood eosinophils, FeNO and total IgE were detected to be biomarkers of eosinophilic airway inflammation for asthmatics. However, whether can they predict the response to corticosteroid in chronic cough remains uncertain. The present prospective, multi-center, randomized placebo-controlled study aims to explore the value of blood eosinophils, FeNO and total IgE in predicting the response to inhaled corticosteroid in patients with chronic cough. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05888350
Study type Interventional
Source The First Affiliated Hospital of Guangzhou Medical University
Contact Kefang Lai, phD
Phone 8156-6841
Email klai@163.com
Status Not yet recruiting
Phase N/A
Start date July 30, 2023
Completion date March 30, 2024

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