To Explore the Related Factors of Cough After Thoracoscopic Pneumonectomy

Cough Clinical Trial

Official title:

Multivariate Analysis of Cough After Uniport Video-assisted Thoracoscopic Surgery Pneumonectomy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04204148
• Other study ID #: 2019113
• Status: Recruiting
• Start date: December 1, 2019
• Est. completion date: April 2020

Study information

• Verified date: December 2019
• Source: The First Affiliated Hospital of Soochow University
• Contact: Jun Zhao
• Phone: 13906130266
• Email: zhaojia0327[@]126.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

To explore the related factors of cough after Uniport video-assisted thoracoscopic surgery pneumonectomy, and to provide theoretical basis and social accumulation of new knowledge for the diagnosis and treatment of cough after pneumonectomy in the future.

Description:

Intractable cough after thoracoscopic pneumonectomy is one of the common complications after pneumonectomy. The incidence of cough can reach 25% ≤ 50%. Cough after operation can aggravate the pain of incision, prolong the hospitalization time, increase the cost of hospitalization, affect the conversation and even sleep of the patients, increase the psychological burden of the patients, and reduce the quality of life of the patients accordingly. Therefore, through this study, the investigators hope to understand the related factors of cough after thoracoscopic pneumonectomy and whether there are predictable risk factors, so as to provide theoretical basis for reducing the occurrence of cough after pneumonectomy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: April 2020
• Est. primary completion date: March 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age = 18 years old, male and female

• Uniport video-assisted thoracoscopic surgery

• No cough symptoms within two weeks before operation

• Informed consent form was signed before operation

Exclusion Criteria:

• Diabetes , heart, brain, liver and kidney diseases

• Chest radiographs / CT in recent months indicate pneumonia

• Pulmonary function cannot tolerate lobectomy / segmental / cuneiform resection

• Distant metastasis patients

• Before operation, there were internal causes of cough (including respiratory tract infectious diseases, pharyngitis, allergic rhinitis, posterior nasal drip syndrome, etc.)

Related Conditions & MeSH terms

• Cough

Locations

Country	Name	City	State
China	The First Affiliated Hospital of Soochow University	Suzhou	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
The First Affiliated Hospital of Soochow University

Country where clinical trial is conducted

China, 

References & Publications (7)

Birring SS, Spinou A. How best to measure cough clinically. Curr Opin Pharmacol. 2015 Jun;22:37-40. doi: 10.1016/j.coph.2015.03.003. Epub 2015 Mar 25. Review. — View Citation

Brignall K, Jayaraman B, Birring SS. Quality of life and psychosocial aspects of cough. Lung. 2008;186 Suppl 1:S55-8. Epub 2007 Oct 16. Review. — View Citation

Dicpinigaitis PV, Rauf K. The influence of gender on cough reflex sensitivity. Chest. 1998 May;113(5):1319-21. — View Citation

Harle ASM, Blackhall FH, Molassiotis A, Yorke J, Dockry R, Holt KJ, Yuill D, Baker K, Smith JA. Cough in Patients With Lung Cancer: A Longitudinal Observational Study of Characterization and Clinical Associations. Chest. 2019 Jan;155(1):103-113. doi: 10.1 — View Citation

Koskela HO, Lätti AM, Pekkanen J. The impacts of cough: a cross-sectional study in a Finnish adult employee population. ERJ Open Res. 2018 Nov 12;4(4). pii: 00113-2018. doi: 10.1183/23120541.00113-2018. eCollection 2018 Oct. — View Citation

Wang P, Zhu M, Zhang D, Guo XG, Zhao S, Zhang XL, Wang DL, Liu CT. The relationship between chronic obstructive pulmonary disease and non-small cell lung cancer in the elderly. Cancer Med. 2019 Aug;8(9):4124-4134. doi: 10.1002/cam4.2333. Epub 2019 Jun 11. — View Citation

Xie MR, Zhu YF, Zhou MQ, Wu SB, Xu GW, Xu SB, Xu MQ. Analysis of factors related to chronic cough after lung cancer surgery. Thorac Cancer. 2019 Apr;10(4):898-903. doi: 10.1111/1759-7714.13021. Epub 2019 Mar 15. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The mean Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC) score before and after surgery	The Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC), which assesses the cough-related quality of life, consists of 19 items divided into three domains: the physical (8 items), psychological (7 items) and social (4 items) domains. A 7-point Likert scale was used to score individual domains. The total scores ranged from 3 to 21, with a higher score indicative of a better health status	The day before surgery,two weeks after surgery,one month after surgery
Secondary	Hospitalization days	The numbers of days of patients stay in the hospital after surgery	From the first days after surgery to discharge,up to 4 weeks
Secondary	Drainage	The total volume of fluid	Measure the volume every 24 hours,up to 4 weeks
Secondary	Anesthesia time	Time from patient anesthesia to extubation	Record total anesthesia during surgery