Cough Clinical Trial - Repeat Doses of BAY1902607 in Healthy Males & Proof

Repeat Doses of BAY1902607 in Healthy Males and Proof of Concept in Chronic Cough Patients

Cough Clinical Trial

Official title:
Two-part, Double-blind, Placebo-controlled, Randomized, Parallel-group Study: (Part 1) in Healthy Male Subjects to Assess Safety and Tolerability of Ascending Repeated Oral Doses of BAY1902607 Including Its Effect on the Pharmacokinetics of a Sub-therapeutic Dose of Midazolam (MDZ), Followed by (Part 2) a Two-way Crossover Administration of Four Different Doses of BAY1902607 in Patients With Refractory Chronic Cough to Assess Safety, Tolerability and Efficacy for Proof of Concept

Status Completed

Clinical Trial Summary

The primary objectives of this study: - To investigate the safety and tolerability of ascending repeated oral doses of BAY1902607 in healthy subjects (Part 1). - To investigate the effect of BAY1902607 on the pharmacokinetics (PK) of a sub-therapeutic 1 mg dose of midazolam (Part 1). - To investigate the safety, tolerability and efficacy of BAY1902607 in patients with refractory chronic cough (Part 2).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Cough

Clinical Trial Details

NCT number	NCT03535168
Study type	Interventional
Source	Bayer
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	May 29, 2018
Completion date	October 11, 2019

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