Cough Clinical Trial
Official title:
The Efficacy of Capsaicin Sensitivity Testing in Patients With Irritable Larynx Syndrome
Irritable larynx syndrome (ILS) is a hyperkinetic laryngeal dysfunction that is characterized
by a persistent cough, voice changes, or breathing difficulties, which are often triggered by
an irritant. Diagnosis of ILS is difficult and typically made via a thorough review of the
clinical history and, occasionally, the patient's reaction to an odor-provocation test.
Standard treatment for ILS is behavioural therapy with a speech language pathologist (SLP),
which provides symptom improvement for most patients. However, currently, there are no
objective measures of the upper airway hyper-responsiveness in this condition to assist in
diagnosing and monitoring disease severity.
Since the cough is irritant-based, it is anticipated that patients with ILS will have a
hypersensitivity to the irritant capsaicin. Capsaicin is the active component of chili
peppers and is what makes them hot. The capsaicin cough challenge is a well recognized test
that involves inhaling different concentrations of capsaicin solutions to determine a cough
reflex sensitivity.
The purpose of this research study is to confirm that ILS patients have a hypersensitivity to
capsaicin compared to healthy volunteers. If a hypersensitivity is observed in ILS patients,
the second objective of this study will be to see if behavioural therapy improves the cough
reflex sensitivity in this patient population.
The proposed study has two purposes; the first is to utilize capsaicin cough challenge to demonstrate an increased efferent receptor sensitivity level in ILS subjects as compared to a control group. The second is to determine if there is an objective change in capsaicin cough challenge results after behavioral therapy, and whether it correlates to the subjective improvement. Self-reporting measures include two validated cough quality of life (QoL) questionnaires collected at the same intervals as the capsaicin testing. ;
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