Cough Clinical Trial
Official title:
Pilot Study Investigating Central Sensitisation of the Cough Reflex in Subjects With Chronic Cough and Healthy Volunteers
Central sensitisation is an increase in the excitability of nerves within the central
nervous system, which can lead to heightened sensitivity to certain stimuli. This process is
involved in some chronic pain conditions e.g. migraines and non−cardiac chest pain. Recent
work by our group suggests central sensitisation may be an important mechanism leading to
chronic cough.
The main questions in this study include:
1. Can the investigators induce temporary central sensitisation of the cough reflex in
healthy volunteers for testing of new medications?
2. Can the investigators demonstrate exaggerated sensitisation in patients with chronic
cough (indicating these patients are already centrally sensitised)?
In animal studies, acid infusion into the gullet (oesophagus) is able to induce central
sensitisation of the cough reflex. Acid infusion into the oesophagus has also been shown to
induce central sensitisation in human healthy volunteers, increasing the sensitivity to pain
on the front of the chest but this study did not test the the cough reflex. Using human
participants, the investigators plan to test whether acid infusion into the oesophagus
increases the sensitivity of the cough reflex in healthy volunteers and also patients
complaining of chronic cough.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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