Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT06450613 |
| Other study ID # |
68277917.4.0000.0071 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
January 1, 2018 |
| Est. completion date |
March 31, 2021 |
Study information
| Verified date |
March 2021 |
| Source |
Hospital Israelita Albert Einstein |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Introduction: Liver transplantation(LT) is the gold-standard treatment for unresectable
early-stage HCC within the Milan criteria. However, long waiting time can lead to dropout
from LT candidacy. Local ablative procedures play a key role in the patient care enabling
downsizing. Radiofrequency ablation(RFA) and percutaneous ethanol injection(PEI) are two
valuable non-surgical neoadjuvant alternatives, but the most cost-effective treatment
strategy remains controversial. Purpose: to assess whether RFA is cost-effective compared to
PEI in adult patients with early-stage hepatocellular carcinoma within the Milan criteria.
Methods: a pilot, single-center, randomized, open-label trial, with blinded end-point
assessment, in which PEI was compared with RFA. Patients with early-stage hepatocellular
carcinoma within the Milan criteria, listed for LT and indication for neoadjuvant treatment
were eligible for enrollment. The primary outcome was the complete response rate according to
mRECIST criteria at 60 days after the treatment. Secondary outcomes were the costs, rates and
degrees of complications and the cost-effectiveness analysis of both techniques.
Description:
Hepatocellular carcinoma (HCC) is the fifth most common neoplasm worldwide, with more than
500,000 cases diagnosed annually. Its incidence has been increasing around the world, having
doubled in the last 25 years in the United States and England. American statistics indicate
that mortality from HCC is increasing compared to mortality from the vast majority of other
types of cancer and it is estimated that mortality will double in the next two decades. In
Brazil, an increasing trend in mortality was also observed for both sexes. The average
mortality coefficient for the country was 3.59 deaths per 100 thousand inhabitants, with an
annual linear increase of 0.020 (R2=0.588; p<0.001), being 4.20 deaths per 100 thousand men
for males, with a linear increase of 0.044 (R2=0.81; p<0.001) per year and, for females, 2.98
per 100 thousand women, with an increase of 0.0194 (R2=0.35; p=0.008) per year.
The main etiological agents in the pathogenesis of HCC are chronic liver disease from chronic
infection with hepatitis B (HBV) and hepatitis C (HCV) viruses and other causal factors of
lower incidence such as alcohol abuse, metabolic/autoimmune disorders or environmental
agents. Regarding HBV-mediated HCC, despite the availability of a vaccine against this virus,
the World Health Organization estimates that, globally, 400 million people are chronically
infected with HBV. There is no vaccine for HCV to date.
Proper diagnosis and treatment of HCC involves a multidisciplinary team comprised of
oncologists, hepatologists, surgeons, pathologists, radiologists, and interventional
radiologists. Currently, there are well-defined radiological criteria for the diagnosis of
HCC, with biopsy being restricted to cases of diagnostic doubt. Multiphase cross-sectional
imaging with contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI),
or even contrast-enhanced ultrasound, allows for the non-invasive definitive diagnosis of HCC
in patients considered to be at high risk. The Liver Imaging Reporting and Data System
(universally known by its acronym LI-RADS - Liver Imaging Reporting and Data System), created
in 2008 to address the need to improve the consistency and clarity of communication between
radiologists and healthcare physicians. reference, has high specificity (above 85%) for
patients at risk of HCC. Based on hyperenhancement in the arterial phase (HRFA), in addition
to main criteria such as non-peripheral "washout", "capsule" with enhancement or growth above
the threshold, suspicious nodules are categorized as probably HCC (LR-4) or definitely HCC ,
(LR-5).
Historically, radio and chemotherapy were not very effective in curing HCC and it was
considered that surgical resection and liver transplantation were the only curative therapies
in terms of disease-free survival for patients with HCC, but locoregional therapies such as
ablation have become more effective in curing HCC. become potentially curative. Patients with
preserved liver function or with lesions that require removal of a small non-tumorous liver
mass are the best candidates for surgery. Unfortunately, only a minority of these patients
can be candidates for surgery with definitive curative purposes, either due to the advanced
stage of the disease at diagnosis, limitations in liver function, the presence of large,
multiple tumors and/or located in an unfavorable location for safe resection.
The number of candidates for liver transplantation in relation to the limited supply of
organs is still the main limiting factor for carrying out this procedure in our country. In
Brazil, in May 2006, Ordinance No. 1160 modified the liver distribution criteria for
transplants, implementing the severity criterion of the patient's clinical status, or model
for end-stage liver disease (MELD - (MELD - mModel fFor Eend -sStage Liver Disease (MELD)), a
scoring system that comprises a scale of values from 6 to 40, being considered a
well-established method (AUC=0.78-0.87) as a predictor of three-month mortality in patients
who are still on the waiting list for an organ. As an indicator of the severity of the
recipient's end-stage biochemical dysfunction, the MELD score uses a logarithmic calculation
that involves serum creatinine, bilirubin and International Normalized Ratio (INR), which
evaluates the blood clotting tendency according to the formula: [0.957 x natural logarithm
(Ln) (creatinine mg/dLl) + 0.378 x Ln (bilirubin mg/dlL) + 1.120 x Ln (INR) + 0.643] x 104.(6
) Patients with HCC are classified as a special situation on the transplant list, with an
initial MELD value of 20, as they are at a higher risk of death due to tumor progression, as
well as the development of metastases or clinical decompensation, which can reach the maximum
value of 29 after six months of inclusion on the list, if he has not been transplanted.
Starting in 2016 in the United States and recently in Brazil, with the purpose of making the
patient classification criteria increasingly more effective, it was proposed to adopt the
serum sodium level in the MELD calculation (MELD-Na or MELD-sodium) , for the allocation of
liver grafts. MELD-Na is calculated using the formula "MELD-Na=MELD + 1.32 x (137 - Na) -
[0.033 x MELD*(137 - Na)]", considering the correction of the serum sodium value for the
range of 125-137 mEq/lL and increasing the effectiveness in predicting mortality on the wait
list. Another important factor considered when selecting patients with HCC for liver
transplantation is the estimation of the risk of tumor recurrence in the post-surgical
period. In current clinical practice in our country, this estimate is based on the size and
number of tumor nodules and the presence of macroscopic vascular invasion, as defined in
preoperative imaging studies. The rule proposed by the Milan group for patient selection,
universally called the Milan Criteria (one nodule less than or equal to 5.0 cm or 2 to 3
nodules all less than or equal to 3.0 cm, and without macroscopic vascular invasion) has been
shown to provide survival rates above 70% at 5 years with about a 10% probability of
recurrence. These criteria have been validated by several groups and are widely used to
select candidates in the United States and Europe. Despite its proven usefulness, however, it
is well known that some patients with tumors exceeding these criteria are also potentially
curable by liver transplantation. More recently, with the development of cell and molecular
biology techniques, many molecular markers related to invasion, metastasis, recurrence and
survival have been explored. In hepatocellular carcinomaHCC, DNA ploidy, proliferative
activity of tumor cells, tumor suppressor and promoter genes, cell cycle controllers,
proteinases that degrade the extracellular matrix, adhesion molecules, angiogenic factors and
metabolic genes were considered biomarkers for the malignant phenotype of hepatocellular
carcinoma, and are related to prognosis and therapeutic results.
The waiting time for liver transplantation in patients with HCC is a determining factor for a
better prognosis, as disease progression can exclude them from the Milan Criteria and,
consequently, from the transplant list. This progression rate varies from 7% to 11% in six
months, and approaches 40% in one year. In these cases, it is understood that there is a loss
of the criteria required to remain on the transplant list, with consequent exclusion of the
patient from the waiting list, which is known as "drop-out" from the list. The waiting list
time, which in other countries is around 6 months, in most regions of Brazil reaches more
than a year and, sometimes, even with the special situation of patients with HCC on the list,
the waiting time waiting time can exceed 2 years.
Over the past 30 years, several methods of chemical or thermal tumor destruction have been
developed and clinically tested. Percutaneous ethanol injection (PEI) induces coagulative
necrosis of the lesion as a result of cellular dehydration, protein denaturation and chemical
occlusion of small tumor vessels. Later, thermal ablative therapies emerged and are
classified as hyperthermic treatments (heating tissue to 60°-100°C) - including
radiofrequency ablation (RFA). Most procedures are performed using a percutaneous approach
guided by imaging methods, usually ultrasound and computed tomography.
It is notable that the principles of transplant benefit tend to prevail when the risk of
cancer-related dropout and response to locoregional treatments are taken into account.
Waitlisted candidates beyond accepted limits of transplantability are significantly more
likely to die or be removed from the waitlist than less advanced candidates, but if
prioritized and transplanted early show similar survival compared to hepatocellular
carcinomaHCC less advanced.
There is consensus in the literature that neoadjuvant therapy finds its important role in
reducing the risk of patients on the list within the Milan criteria, since if prioritized and
maintained within the transplantability criteria they have similar survival regardless of
whether or not they have hepatocellular carcinomaHCC. When analyzing the literature including
patients not listed for transplantation, there are few randomized controlled studies that
compare the best neoadjuvant therapy for hepatocellular carcinomaHCC.
A systematic review carried out in 2013 sought an answer to what would be the best treatment
for patients with hepatocellular carcinomasHCC smaller than 3.0 cm, comparing radioblation
(RFA) and percutaneous alcohol injection (PEI)RFA and PEI. They compiled evidence from 4
prospective randomized controlled studies, totaling 766 patients with follow-ups of at least
3 years. They concluded that RFA appears superior to PEI with regard to local tumor control
and 3-year survival, but presents a greater number of complications and higher cost, being
more feasible in patients with hepatocellular carcinomasHCC greater than 2.0 cm or with
function hepatic Child-Pugh A.
Many patients in our country can certainly benefit from this modality, however, we do not yet
have this treatment routinely available in Brazil given the potential high cost of the
instrument, constant denials from supplementary paying sources and little availability in the
public system. Hence the need for studies that aim to discuss conditions for the use of
possible alternative technologies in our environment, such as percutaneous ethanol injection
(PEI)PEI, which has a potential lower cost, but this cost has not yet been evaluated in our
environment.
Patients on the liver transplant waiting list may benefit from percutaneous treatments
involving RFA or PEI, but doubts remain as to whether PEI would have therapeutic
disadvantages, fewer complications and a significantly lower cost compared to RFA.
The aim of this study is to compare the use of RFA with PEI in patients with hepatocellular
carcinoma on the liver transplant waiting list, in relation to radiological response,
complications, cost analysis and cost-effectiveness, as there is, to date, no sufficient
evidence to uniformly support a better cost ratio and post-treatment tumor response
considering the risk of complications, for RFA or PEI in HCCs between 2.0 and 3.0cm,
especially in the national scenario.
It is also worth highlighting that there are no randomized controlled studies on the
efficacy, cost-effectiveness and complications of RFA and PEI for patients with early-stage
hepatocellular carcinomas on the liver transplant list in Latin America and very few
randomized controlled studies published around the world.
