Characteristics in Post Covid-19 Patients

Coronavirus Infection Clinical Trial

Official title:

Clinical Respiratory Investigation in Post Covid-19 Patients

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04514705
• Other study ID #: F110820
• Status: Active, not recruiting
• Phase: N/A
• Start date: August 11, 2020
• Est. completion date: December 31, 2025

Study information

• Verified date: December 2023
• Source: Universidade Metodista de Piracicaba
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To evaluate pulmonary changes and the results of a cardiopulmonary rehabilitation protocol (CPRP) in patients after SARS-VOC-2 infection. Clinical trial type study to be conducted between 2020 and 2024 involving clinical-functional cardiopulmonary imaging and blood transcriptome profile: before CPRP (T1), 2 months after CPRP (T2) and 1 year later (T3). Expected results: a) clinical, image and transcriptome changes; b) clinical-functional improvement after CPRP.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 20
• Est. completion date: December 31, 2025
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• With confirmed diagnosis for SARS-COV-2.

Exclusion Criteria:

• With any type of simultaneous pneumopathy.

• Patients with autoimmune disease

• People with simultaneous infectious diseases

• Pregnant women

• With degenerative diseases of the nervous system or musculoskeletal system

Related Conditions & MeSH terms

• Coronavirus Infection
• Coronavirus Infections

Intervention

Other:
• Exercise
Exercise with treadmil and weight training station

Locations

Country	Name	City	State
Brazil	Universidade do Estado do Pará	Belém	Pará

Sponsors (1)

Lead Sponsor	Collaborator
Universidade Metodista de Piracicaba

Country where clinical trial is conducted

Brazil, 

References & Publications (6)

Abdullahi A, Bello B, Mukhtar NB, Kaka B, Abba MA, Usman JS, Shittu A, Mayana KI, Maiwada SA, Mohammed J. Physiotherapy management of COVID-19 in Africa: Ongoing efforts, challenges, and future directions. Physiother Theory Pract. 2020 Aug;36(8):871-872. — View Citation

Grigoletto I, Cavalheri V, Lima FF, Ramos EMC. Recovery after COVID-19: The potential role of pulmonary rehabilitation. Braz J Phys Ther. 2020 Nov-Dec;24(6):463-464. doi: 10.1016/j.bjpt.2020.07.002. Epub 2020 Jul 19. No abstract available. — View Citation

Kamalakannan S, Chakraborty S. Occupational therapy: The key to unlocking locked-up occupations during the COVID-19 pandemic. Wellcome Open Res. 2020 Jul 1;5:153. doi: 10.12688/wellcomeopenres.16089.1. eCollection 2020. — View Citation

Rooney S, Webster A, Paul L. Systematic Review of Changes and Recovery in Physical Function and Fitness After Severe Acute Respiratory Syndrome-Related Coronavirus Infection: Implications for COVID-19 Rehabilitation. Phys Ther. 2020 Sep 28;100(10):1717-17 — View Citation

Saeki T, Ogawa F, Chiba R, Nonogaki M, Uesugi J, Takeuchi I, Nakamura T. Rehabilitation Therapy for a COVID-19 Patient Who Received Mechanical Ventilation in Japan. Am J Phys Med Rehabil. 2020 Oct;99(10):873-875. doi: 10.1097/PHM.0000000000001545. — View Citation

Torlinski T, Rakasz L, Wysota B, Czyz M, Snelson C. An interdisciplinary approach to the management of critically ill patients during covid-19 pandemic; an experience of a university hospital in England. Wiad Lek. 2020;73(7):1576-1579. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Characteristics of lung	In the supine position, the patient will perform deep inspiration followed by momentary apnea inside the high resolution scanner to capture cross-sectional images of the chest with smaller cuts than 1mm of collimation which helped in the detection of even small lesions.	post treatment in 3 days
Primary	Respiratory muscle strength	Respiratory muscle strength will be assessed using the digital manovacuometer. The measurement will be performed as follows the patient will be asked to empty the lungs to the residual volume and then perform an inhalation until the total lung capacity.	post treatment in 3 days