Clinical Trials Logo
  1. Home
  2. Coronary Artery Bypass
  3. NCT05010460

Study of Roxadustat for Reducing the Incidence of Acute Kidney Injury After Coronary Artery Bypass Grafting

Coronary Artery Bypass Clinical Trial

Official title:
Roxadustat Reduces the Incidence of Acute Kidney Injury After Coronary Artery Bypass Grafting: a Multicenter, Randomized, Double-blind, Placebo-controlled Study

Clinical Trial Summary

Acute kidney injury is a frequent complication after coronary artery bypass grafting (CABG). Roxadustat is a prolyl hydroxylase inhibitor (PHI) which can stabilize hypoxia-inducible factor (HIF) and improve the hypoxic tolerance of tissues. Roxadustat has shown effect in reducing acute kidney injury in animal studies. This study aims to evaluate the efficacy of administration of Roxadustat before surgery in the prevention of acute kidney injury after CABG.

Clinical Trial Description

Acute kidney injury is a frequent complication after coronary artery bypass grafting (CABG), with a incidence of 28-38%. Renal ischemia-reperfusion injury is the main mechanism for acute kidney injury after CABG. Roxadustat is a kind of prolyl hydroxylase inhibitor (PHI) which can stabilize hypoxia-inducible factor (HIF) and improve the hypoxic tolerance of tissues. Roxadustat has shown effect in reducing acute kidney injury in animal studies. This study aims to evaluate the efficacy of administration of Roxadustat (before surgery) in the prevention of acute kidney injury after CABG. This is a multicenter, randomized, double-blind, placebo-controlled study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05010460
Study type Interventional
Source Peking Union Medical College Hospital
Contact Sanxi Ai, Doctor
Phone +861069156874
Email sanxiai@163.com
Status Recruiting
Phase Phase 2
Start date September 30, 2021
Completion date October 30, 2023
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT03235323 - Efficacy of External CounterPulsation for Postoperative Coronary Artery Bypass Grafting Patients N/A
Completed NCT05036044 - Stroke and Carotid-Cerebral Vascular Disease After CABG
Completed NCT03622671 - Fibrin Clot Properties and Blood Loss Following Coronary Artery By-pass Grafting N/A
Completed NCT00400790 - Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane N/A
Not yet recruiting NCT03275220 - Assessment Of Right Ventricular Function In Patients Undergoing Coronary Artery Bypass Graft In Assiut University N/A
Completed NCT01256372 - An Trial of Two Dosing Regimens of AP214 for the Prevention of Kidney Injury in Patients Undergoing Cardiac Surgery Phase 2
Completed NCT00489827 - Glutamate for Metabolic Intervention in Coronary Surgery Phase 3
Completed NCT04591119 - Transversus Thoracis Muscle Plane Block for Postoperative Pain in Adult Cardiac Surgery N/A
Active, not recruiting NCT03908593 - Proton Pump Inhibitor Preventing Upper Gastrointestinal Injury In Patients On Dual Antiplatelet Therapy After CABG Phase 4
Recruiting NCT03774342 - The Influence of Cognitive Decline on Quality of Life After Coronary Bypass
Enrolling by invitation NCT03999398 - Short and Long-term Results of PCI in no Touch Vein-graft.
Recruiting NCT05414331 - WithDRawal Impact Of Postoperative Beta-Blocker N/A
Completed NCT02981680 - Effect of Remote Ischemic Preconditioning on the Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery N/A
Completed NCT00600704 - Impact of Fluid Restriction Policy in Reducing the Use of Red Cells in Cardiac Surgery N/A
Completed NCT06013605 - Effect of Walking Exercise on Functional Capacity and Productivity in Patients After Coronary Artery Bypass Graft N/A
Active, not recruiting NCT02731794 - On-pump Beating Coronary Artery Bypass Grafting by Ventricular Assist Phase 4
Completed NCT02722213 - Mindfulness & Stress Management Study for Cardiac Patients N/A
Completed NCT01285271 - A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon Phase 3
Completed NCT00823082 - Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass Phase 2
Completed NCT00911976 - Study of the Xience V Everolimus-eluting Stent in Saphenous Vein Graft Lesions Phase 4