Effect of Prime Solution on Fluid Balance After Open Heart Surgery

Status Completed

Clinical Trial Summary

The use of Tetraspan® as prime solution can reduce fluid extravasation after perfusion versus Ringer acetate. Plasma-adapted HES-solutions produce also less acidosis.

Clinical Trial Description

Fifty patients scheduled for elective primary and single cardiac surgery include in this prospective study. Patients with preoperative coagulation disorders, or renal or hepatic failure, are excluded.

Before admission to the operation theatre, the patients allocate in random order to receive one of the following solutions during the extracorporeal circulation:

1. Ringer-acetate solution

2. 6% HES solution (Tetraspan®) During the 1 postoperative day we register hemodynamic changes, fluid balance, fluid extravasation, plasma ion concentration, modified thromboelastography, and kidney function. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00797589
Study type	Interventional
Source	Helsinki University
Contact
Status	Completed
Phase	Phase 4
Start date	January 2009
Completion date	September 2012

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04566497` - Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up.	N/A
Completed	`NCT01850082` - Randomized Endo-Vein Graft Prospective	N/A
Not yet recruiting	`NCT04657835` - Assessment of Atrial Cardiomyopathy Using MRI as a Predictor of Cardiac Post-Operative Atrial Fibrillation After Cardiac Surgery.	N/A
Completed	`NCT02889562` - Apixaban Versus Warfarin for the Management of Post-operative Atrial Fibrillation	Phase 2/Phase 3
Completed	`NCT01528514` - Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study	N/A
Completed	`NCT01378221` - VItamin D Metabolism in SEnescent Cardiac Surgery Patients	N/A
Completed	`NCT00848796` - Comparative Study of Two Brands of Heparin Already on the Market	N/A
Not yet recruiting	`NCT05552586` - Melatonin Impact on the Outcomes of Myocardial Ischemia/Reperfusion Injury During Coronary Artery Bypass Grafting Surgery	N/A
Completed	`NCT00246740` - Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting	Phase 2
Completed	`NCT00420667` - Low Molecular Weight Heparin vs Unfractionated Heparin at Cardiac Surgery	N/A
Recruiting	`NCT04197700` - The PRESSURE CABG Cardiac Surgery Trial	N/A
Not yet recruiting	`NCT05835167` - Complete Revascularization Via Inferior Part-sternotomy	N/A
Not yet recruiting	`NCT06326996` - Thiamine Intervention and Coronary Artery Bypass Grafting	N/A
Not yet recruiting	`NCT02732574` - Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery	N/A
Completed	`NCT00903604` - Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery	Phase 2
Completed	`NCT01182688` - Prospective Review of Procalcitonin After Cardiac Surgery	N/A
Completed	`NCT02737215` - Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Obstructive Sleep Apnea	N/A
Recruiting	`NCT03209414` - Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
Recruiting	`NCT05441358` - Assessment of Platelet Function in Patients Undergoing Open Heart Surgery
Recruiting	`NCT02400125` - China Cardiovascular Surgery Registry	N/A