Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells

Status Recruiting

Clinical Trial Summary

The proposed Conventional Cohort Expansion Study involves the use of Mesenchymal Stromal Cells (MSCs) are derived from the bone marrow. We previously studied the safety of subconjunctival injection of allogeneic bone marrow-derived MSCs in patients with nonhealing epitheliopathy (IRB Protocol 2020-0334). In the present study, we want to study the efficacy of this treatment on chronic epitheliopathies.

Clinical Trial Description

The "Efficacy of Locally Delivered Allogeneic Mesenchymal Stem Cells for Promoting Corneal Repair Study" otherwise known as the "MSC Study," is designed to assess the safety of allogeneic bone marrow-derived MSC secreted factor on the ocular surface via subconjunctival injection of MSC, and also obtain a preliminary observation on the following: - Epithelial barrier integrity and/or wound closure. - Development of Scarring. - Final Visual Acuity. The objective is to improve clinical outcomes in significant non-healing corneal wounds. To achieve these goals, the MSC Study will include a Phase II efficacy study. ;

Study Design

Related Conditions & MeSH terms

Corneal Ulcer

Clinical Trial Details

NCT number	NCT05705024
Study type	Interventional
Source	University of Illinois at Chicago
Contact	Ali R Djalilian, MD
Phone	312-996-8937
Email	adjalili@uic.edu
Status	Recruiting
Phase	Phase 2
Start date	September 29, 2023
Completion date	September 28, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02731638` - Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers	Phase 3
Completed	`NCT00324168` - Steroids for Corneal Ulcers Trial	Phase 4
Completed	`NCT04484402` - Treatment of Patients With Inflammatory-dystrophic Diseases of the Cornea Using Autologous Stem Cells	Phase 1/Phase 2
Completed	`NCT04820010` - Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Recruiting	`NCT02570321` - Cross-linking for Corneal Ulcers Treatment Trial	Phase 4
Completed	`NCT00386958` - A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers	Phase 2
Completed	`NCT04054817` - ACRO Biocornea Clinical Trial in Taiwan	N/A
Completed	`NCT00997035` - The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo	Phase 3
Completed	`NCT02277054` - Safety and Effectiveness of Collagen-phosphorylcholine Bioengineered Cornea in Patients Requiring Lamellar Keratoplasty	N/A
Recruiting	`NCT05313828` - Effect of Various Treatment Modalities on Dendritic Vial Ulcer
Recruiting	`NCT05255107` - Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Previously Untreated Corneal Ulcers	Phase 2/Phase 3
Recruiting	`NCT05255016` - Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal Ulcers	Phase 2/Phase 3
Completed	`NCT05891106` - AONDA Therapeutic Indication Study I
Terminated	`NCT00789646` - Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients	N/A
Not yet recruiting	`NCT05940376` - Topical Insulin in Neurotrophic Keratopathy After Diabetic Vitrectomy
Completed	`NCT05200000` - Wharton's Jelly Eye Drops in the Treatment of Chronic Keratitis	Phase 1
Completed	`NCT01756456` - Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis.	Phase 1/Phase 2
Active, not recruiting	`NCT01969786` - Village Integrated Eye Workers Trial	N/A
Completed	`NCT01794312` - Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer	Phase 3
Completed	`NCT04837534` - Improving the Follow up Rate for Pediatric Patients	N/A