Photodynamic Therapy With Verteporfin for Corneal Neovascularization

Status Completed

Clinical Trial Summary

Purpose: To investigate the efficacy of photodynamic therapy with verteporfin for the treatment of patients with corneal neovascularization.

Design: Prospective, non-comparative case series. Participants: Eighteen eyes of 18 patients with stable corneal neovascularization who were refractory to conventional treatment.

Methods: The patients were treated with photodynamic therapy with verteporfin (6 mg/m2). Five patients were treated following penetrating keratoplasty, and 2 patients were treated before penetrating keratoplasty. Best corrected visual acuity and anterior segment photography were performed before and after treatment. The length of cumulative blood vessels and area of corneal neovascularization were measured.

Main outcome measures: Vascular occlusion, best corrected visual acuity, cumulative blood vessel length, and corneal neovascularization area.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00471406
Study type	Interventional
Source	Chonnam National University Hospital
Contact
Status	Completed
Phase	N/A

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00555594` - Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization	Phase 2/Phase 3
Completed	`NCT00004430` - Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization	N/A
Completed	`NCT00769145` - Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery	Phase 1
Completed	`NCT01257750` - Treatment of Corneal Neovascularization With Topical Pazopanib	Phase 1/Phase 2
Recruiting	`NCT04787471` - Corneal Crosslinking for Treatment of Corneal Neovascularization	Phase 2/Phase 3
Not yet recruiting	`NCT06412718` - Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
Active, not recruiting	`NCT00992849` - Bevacizumab for the Treatment of Corneal Neovascularization	Phase 2
Withdrawn	`NCT00515684` - Corneal Thinning During Topical Bevacizumab Therapy	N/A
Terminated	`NCT02797704` - Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization	Phase 1/Phase 2
Terminated	`NCT01868360` - Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea	Phase 1
Withdrawn	`NCT02042027` - Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions	Phase 1
Recruiting	`NCT04215393` - An Exploratory Clinical Trial Evaluating the Tolerability and Efficacy of KH906 in Patients With Corneal Neovascularization	Phase 1
Completed	`NCT00797303` - The Effect of Bevacizumab on Corneal Neovascularization	Phase 4
Recruiting	`NCT05659940` - Correlation Between a Novel Subset of Neutrophil and Corneal Neovascularization.
Completed	`NCT00559936` - Topical Avastin for Treatment of Corneal Neovascularization	Phase 1
Completed	`NCT01072357` - Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival	Phase 1/Phase 2
Recruiting	`NCT04620109` - Clinical Evaluation of Safety and Tolerability of KDR2-2 Eye Drops in Healthy Volunteers With Pharmacokinetic Assessment	Phase 1
Completed	`NCT00512876` - Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization	N/A
Recruiting	`NCT05011916` - The Safety and Efficacy of KDR2-2 Suspension Eye Drops in the Treatment of Corneal Neovascularization	Phase 1/Phase 2
Completed	`NCT01996826` - A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival	Phase 1/Phase 2