Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK

Corneal Epithelial Wound Healing Clinical Trial

Official title:

Effect of Gatifloxacin 0.3% and Moxifloxacin 0.5% on Epithelial Wound Healing After Photorefractive Keratectomy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00569881
• Other study ID #: Donnenfeld2
• Status: Completed
• Phase: N/A
• First received: December 6, 2007
• Last updated: December 7, 2007
• Start date: January 2007
• Est. completion date: March 2007

Study information

• Verified date: December 2007
• Source: Donnenfeld, Eric, M.D.
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: None Needed
• Study type: Observational

Clinical Trial Summary

The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target tissue, and be safe and not toxic to any layer of the healing cornea, especially the epithelium. Several studies have investigated the toxicity of the fourth generation fluoroquinolones on the corneal epithelium and studies have demonstrated that gatifloxacin is less deleterious to the healing cornea than moxifloxacin. Most of these studies, however, have been conducted in animals. This was a retrospective chart review.

Description:

Prior generation fluoroquinolones predominantly either inhibit topoisomerase II (DNA Gyrase) or topoisomerase IV and therefore only require one genetic mutation for bacteria to develop resistance. Fourth-generation fluoroquinolones are equally effective against topoisomerase II and IV, which significantly expands their spectrum of action against gram-positive agents and atypical mycobacteria and Nocardia . This duality of action of the fourth generation fluoroquinolones requires that for bacteria to become resistant to these agents, the bacteria must undergo two genetic mutations resulting in a significantly decreased chance of an organism developing resistance.Minimum inhibitory concentrations determined in vitro suggest that fourth-generation fluoroquinolones are more effective than second- and third-generation fluoroquinolones against gram-positive bacteria including Staphylococcal species found in endophthalmitis and bacterial keratitis cultures. The increased efficacy of fourth-generation fluoroquinolones make these antibiotics important agents to evaluate for prophylaxis against post-PRK infections. This was a retrospective chart review.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: March 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients were eligible for inclusion if they were a healthy male or female 18 years of age or older and were candidates for bilateral PRK.

• Eligible patients had a best-corrected Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity score equivalent to a Snellen score of 20/30 or better in each eye, had a stable prescription for 1 year, were willing to participate in the study, and were able to comprehend and sign the informed consent form.

• All subjects were instructed that if they decide not to participate they could withdraw from the study at any time.

Exclusion Criteria:

• Patients were excluded from the study if they had a history of refractive or other ocular surgery in either eye.

• Patients with any condition which could delay wound healing were not eligible to participate.

• They were excluded if they had poor tolerance to any component of the masked study fluoroquinolones, Acular® LS (Allergan) or Pred Forte® (Allergan).

• Patients were also excluded if they required the use of a systemic antibiotic during the study period, were involved in another investigational study or had participated in a study within 30 days prior to the start of this study.

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Corneal Epithelial Wound Healing

Intervention

Drug:
• gatifloxacin and moxifloxacin
Comparison of wound healing between drugs

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Donnenfeld, Eric, M.D.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Wound Healing		Days after PRK	No