Cornea Ectasia Excimer Laser Treatment

Status Completed

Clinical Trial Summary

To evaluate efficacy, safety, objective and subjective quality of vision after treatment of cornea ectasia with transepithelial topographic guided laser simultaneous Central Corneal Remodeling (CCR) and Cross-linking (CXL).

Clinical Trial Description

Background To evaluate efficacy, safety, objective and subjective quality of vision after treatment of cornea ectasia performed with transepithelial topographic guided laser simultaneous Central Corneal Remodeling (CCR) and Cross-linking (CXL).

Methods In this retrospective study 8 eyes of 8 patients (mean age 31.50±14.73 years) affected by cornea ectasia underwent simultaneous CCR and CXL. Preoperative and 6 month postoperative uncorrected distance visual acuity (UDVC) and distance corrected visual acuity (DCVA) were measured using the Efficacy and Safety index. Objective and subjective quality of vision were evaluated preoperatively and 6 months postoperatively using corneal morphological irregularity index (CMI), National Eye Institute Visual Function NEI-VFQ25 and NEI-VFQ39 questionnaires. ;

Study Design

Related Conditions & MeSH terms

Corneal Ectasia

Clinical Trial Details

NCT number	NCT04405882
Study type	Observational
Source	Bambino Gesù Hospital and Research Institute
Contact
Status	Completed
Phase
Start date	October 1, 2019
Completion date	April 30, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03319082` - Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refractive Surgery
Recruiting	`NCT02009709` - Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2	Phase 1
Recruiting	`NCT04094090` - Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia	Phase 2
Active, not recruiting	`NCT01464268` - Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia	Phase 3
Active, not recruiting	`NCT04763785` - Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Images
Recruiting	`NCT01325298` - UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia	Phase 2
Recruiting	`NCT04251143` - Dresden Corneal Disease and Treatment Study
Active, not recruiting	`NCT01152541` - Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin	Phase 3
Recruiting	`NCT04905108` - Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia	Phase 3
Recruiting	`NCT04401865` - Safety and Effectiveness of the PXL-Platinum 330 System	Phase 1/Phase 2
Completed	`NCT05691335` - Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus	N/A
Completed	`NCT04475900` - Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics
Recruiting	`NCT05027295` - Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light	Phase 3
Completed	`NCT03913338` - Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia	N/A
Withdrawn	`NCT01643252` - Safety and Efficacy Study for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery	Phase 3
Terminated	`NCT01459679` - Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery	Phase 3
Active, not recruiting	`NCT04698590` - Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism	N/A
Completed	`NCT04177082` - Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution	Phase 1
Recruiting	`NCT06347900` - Corneal Topographic Changes in Different Grades of OSA
Completed	`NCT06348368` - Refractive and Corneal Topographic Characteristics in Upper Egypt Children With High Cylinder