Clinical Trials Logo

Clinical Trial Summary

Prospective, randomized, single site study to determine the safety and effectiveness of performing corneal collagen cross-linking (CCCL)using riboflavin and UVA light in eyes with corneal ectasia or progressive keratoconus.


Clinical Trial Description

Subjects are randomized to a control group or a treatment group, with the control group crossed over to the treatment group at the 3 month visit. Corneal collagen cross-linking is performed as a single treatment. Subjects are followed for at least 12 months to evaluate the long term effects of corneal collagen cross-linking.

Subjects may be referred from other physicians but must return to Emory Vision for completion of all study visits. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00567671
Study type Interventional
Source Emory University
Contact
Status Completed
Phase Phase 2/Phase 3
Start date December 2007
Completion date June 2010

See also
  Status Clinical Trial Phase
Recruiting NCT03319082 - Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refractive Surgery
Recruiting NCT02009709 - Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2 Phase 1
Recruiting NCT04094090 - Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia Phase 2
Completed NCT04405882 - Cornea Ectasia Excimer Laser Treatment
Active, not recruiting NCT01464268 - Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Phase 3
Active, not recruiting NCT04763785 - Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Images
Recruiting NCT01325298 - UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Phase 2
Recruiting NCT04251143 - Dresden Corneal Disease and Treatment Study
Active, not recruiting NCT01152541 - Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin Phase 3
Recruiting NCT04905108 - Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia Phase 3
Recruiting NCT04401865 - Safety and Effectiveness of the PXL-Platinum 330 System Phase 1/Phase 2
Completed NCT05691335 - Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus N/A
Completed NCT04475900 - Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics
Recruiting NCT05027295 - Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light Phase 3
Completed NCT03913338 - Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia N/A
Withdrawn NCT01643252 - Safety and Efficacy Study for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Phase 3
Terminated NCT01459679 - Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Phase 3
Active, not recruiting NCT04698590 - Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism N/A
Completed NCT04177082 - Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution Phase 1
Recruiting NCT06347900 - Corneal Topographic Changes in Different Grades of OSA