The Role of Computed Tomography in the Phenotyping of COPD Patients

COPD Clinical Trial

Official title:

The Role of Computed Tomography in the Phenotyping of COPD Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05747235
• Other study ID #: CT in COPD phenotyping
• Status: Completed
• Start date: April 1, 2022
• Est. completion date: December 31, 2023

Study information

• Verified date: February 2024
• Source: Aswan University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease that is characterized by respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases. the CT was used for classification of COPD patients into different phenotypes: phenotype A that has minimal emphysema with or without airway disease, phenotype E that has emphysema without airway disease, and finally phenotype M as a mixed form. The investigators aimed to to identify the phenotypes of COPD using radiologic data obtained by computed tomography. Moreover, this study will be designed to answer the questions about possible correlation between pulmonary function parameters and CT.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: December 31, 2023
• Est. primary completion date: March 30, 2023
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• All stable COPD patients that lastly confirmed to have the disease based on spirometry and past clinical history according to GOLD (2022).

• Age above 18 years.

Exclusion Criteria:

• COPD patients associated with other chest diseases as collapse

• COPD patients associated with consolidation

• COPD patients unable to perform spirometry

Related Conditions & MeSH terms

• COPD

Intervention

Radiation:
• CT chest
All patients will undergo MSCT chest at both inspiratory and expiratory phases in supine position without any contrast media.

Locations

Country	Name	City	State
Egypt	Islam Galal Sayed	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Aswan University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Fan L, Xia Y, Guan Y, Zhang TF, Liu SY. Characteristic features of pulmonary function test, CT volume analysis and MR perfusion imaging in COPD patients with different HRCT phenotypes. Clin Respir J. 2014 Jan;8(1):45-54. doi: 10.1111/crj.12033. Epub 2013 Jul 31. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Identifying the different phenotypes of COPD using HRCT	Identifying the different phenotypes of COPD using HRCT. moreover, to identify whether there is a possible correlation between CT phenotypes and FEV1, FVC or FEV1/FVC.	one month