Cognitive Impairment and Upper Extremity Performance in COPD

COPD Clinical Trial

— COPD  

Official title:

Comparison of Upper Extremity Functional Capacity, Respiratory Functions, Fatigue and Quality of Life in Chronic Obstructive Pulmonary Patients With and Without Cognitive Impairment

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05137483
• Other study ID #: IKC125
• Status: Not yet recruiting
• Start date: November 19, 2021
• Est. completion date: July 30, 2022

Study information

• Verified date: November 2021
• Source: Izmir Katip Celebi University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Within the scope of this study, COPD patients will be divided into two groups according to cognitive dysfunction.

Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment Scale, 6 min pegboard ring test, grip strength measurement, Fatigue Impact Scale and St.George Respiratory Questionnaire will be applied to the groups.

Description:

Although the mechanism of cognitive dysfunction in COPD is not clear, the reasons focused on are; decreased oxygen use, high carbon dioxide levels, increased inflammation and oxidative stress, decreased physical activity, peripheral vascular diseases, atherosclerosis, high or low blood pressure, cerebral vasoconstriction, increased intracranial pressure, accompanying comorbidities, smoking and genetic predisposition, brain damage and exacerbations have been reported. Few studies have shown that cognitive dysfunction is associated with functional performance. There are no studies on the effect of cognitive function on upper extremity performance and mechanisms of action in COPD patients.

The aim of this study is to compare upper extremity functional capacities, respiratory functions, fatigue and quality of life in COPD patients with and without cognitive function impairment.

Within the scope of this study, COPD patients will be divided into two groups according to cognitive dysfunction.

Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment Scale, 6 min pegboard ring test, grip strength measurement, Fatigue Impact Scale and St.George Respiratory Questionnaire will be applied to the groups.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 80
• Est. completion date: July 30, 2022
• Est. primary completion date: June 30, 2022
• Gender: All
• Age group: 45 Years and older

Eligibility

Inclusion Criteria:

• Volunteering to participate in the study

• Stage 2-3-4 according to the GOLD classification in the 40-65 age range

Exclusion Criteria:

• Exacerbation of respiratory symptoms in the past 4 weeks (change in breathlessness and/or sputum volume/color, need for antibiotic treatment or need for hospitalization)

• Presence of asthma, unstable coronary heart disease, uncontrolled diabetes, hypertension, left-sided congestive heart failure, neoplasia, severe claudication, encephalitis or epilepsy

• Having a history of head trauma or brain tumor

• Having a significant psychiatric condition or the presence of defined dementia, according to the American Psychiatric Association

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Cognitive Impairment
• COPD
• Upper Extremity
• Upper Limb Function

Intervention

Other:
• Functional tests
We will apply upper extremity performance tests, hand grip measurements, and scales measuring fatigue and quality of life to the groups.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Izmir Katip Celebi University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	6 min. pegboard ring test	It is used to measure upper extremity functional capacity.	6 minutes
Secondary	Mini Mental State Test	It is used for measuring cognitive impairment	15 minutes
Secondary	Montreal Cognitive Assessment Scale	It is used for measuring cognitive impairment	30 minutes
Secondary	Respiratory Function Test	It is used for measuring lung functions and respiratory muscle strength	20 minutes
Secondary	Fatigue Impact Scale	It is used for measuring fatigue level	Time Frame: 20 minutes
Secondary	St. George Respiratory Questionnaire	It is used for measuring desase-related quality of life	20 minutes
Secondary	COPD Assessment Test	It is used for measuring health status of COPD patients	10 minutes
Secondary	mMRC Dyspnea Scale	It is used for measuring dyspnea sensation in daily living activities	5 minutes