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Clinical Trial Summary

To Evaluate the Outcome of cardio selective beta1 (β1-) blockers use in patients with chronic obstructive pulmonary disease. Patient education about the COPD and their medications.


Clinical Trial Description

Chronic obstructive pulmonary disease (COPD) is a common preventable and Treatable airway disorder characterized by symptoms such as dyspnea, chronic Cough, and sputum production along with persistent airflow limitation that is not fully Reversible. Evidence provided by post hoc analysis of clinical trials and large observational studies suggests a beneficial effect of beta-blockers on mortality and exacerbation in mild to moderate COPD patients. Evidence concerning cardio selective B blockers. Over the past 20 years' non selective B blockers have largely been replaced with cardio selective blockers. Cardio selective beta blockers such as atenolol and metoprolol are at least 20 times more potent at blocking B-1 receptors than B-2 receptors. At therapeutic doses the B-1 blocking effect, and therefore the risk of bronco constriction, is negligible. In addition there is strong evidence that B-blocked cause up-regulation and sensitization of B-receptors. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04845061
Study type Interventional
Source Ain Shams University
Contact asma suliman, bachelor
Phone 00201006279989
Email asma.shain2017@gmail.com
Status Recruiting
Phase Phase 4
Start date October 1, 2021
Completion date January 15, 2022

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