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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03240198
Other study ID # MB2PROF
Secondary ID
Status Recruiting
Phase N/A
First received September 23, 2016
Last updated August 29, 2017
Start date January 2010
Est. completion date January 2021

Study information

Verified date August 2017
Source Centre Hospitalier Intercommunal Creteil
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Chronic obstructive pulmonary disease (COPD) is a frequent disease, mainly linked to tobacco smoking leading to chronic respiratory failure. It is characterized by an inflammatory spate with modification of protease-antiprotease and oxidant-antioxydant balances. Local modifications are associated with systemic changes. Many occupational factors have been associated with an excess of COPD in epidemiological studies, however without identification of any specific clinical or biological phenotype.

Pathophysiological pathways involved in COPD might be different according to etiologic agents. Therefore, it is important to focus research on blood biomarkers associated with some well-characterized occupational COPD.

The objectives of MB2PROF project are:

1. To build the first multicentric cohort of cases of occupational COPD, with collection of plasma and DNA samples,

2. To study the evolution of clinical and lung function parameters of occupational COPD in comparison with non occupational COPD during a follow-up study,

3. To identify biological phenotypes of COPD associated to a given etiological agent.

The methodology includes:

1. The constitution of a cohort with a clinical and biological follow-up during 5 years. Subjects will be recruited in 7 occupational diseases departments, with the collaboration of Pneumology departments.

Four groups of males subjects will be recruited (G1 : occupational COPD (6 groups of 60 subjects, corresponding to 6 groups of occupational agents) ; G2 : non occupational COPD (n = 60) ; G3 : subjects with similar occupational exposure to G1 subjects but without COPD (6 groups of 60 subjects) ; G4 : subjects free of occupational exposure and of COPD (n = 60)), paired on tobacco-smoking and age. For each subject, information on clinical data, lung function parameters, occupation history and blood samples will be collected.

2. The identification of biomarkers, using proteomic and genomic approaches according to subgroups (with different etiologies) of occupational COPD,

3. The study of molecular pathways identified in these subgroups, with in vitro and in vivo studies The MB2PROF project is an original and ambitious multidisciplinary and translational project. The constitution of well-characterized COPD cases cohort should allow the identification of biomarkers and molecular pathways associated with some subgroup of subjects, and improve the knowledge of mechanisms involved.


Recruitment information / eligibility

Status Recruiting
Enrollment 400
Est. completion date January 2021
Est. primary completion date January 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 40 Years to 80 Years
Eligibility Inclusion Criteria:

- COPD

Exclusion Criteria:

- Other obstructive disease

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
France CHI Créteil Créteil

Sponsors (7)

Lead Sponsor Collaborator
Centre Hospitalier Intercommunal Creteil Centre Hospitalier Le Havre, Centre Hospitalier Universitaire de Besancon, Henri Mondor University Hospital, University Hospital, Bordeaux, University Hospital, Caen, University Hospital, Lille

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary C Protein Reactive at year 1
Primary blood inflammatory markers at year 1
Secondary C Protein Reactive every year during 5 years
Secondary blood inflammatory markers every year during 5 years
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