The Assessment of Airway Resistance and Airtrapping in Elderly COPD Patients by Forced Oscillation Technique (FOT)

COPD Clinical Trial

Official title:

The Assessment of Airway Resistance and Airtrapping in Elderly COPD Patients by Forced Oscillation Technique (FOT)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01553812
• Other study ID #: KW/EX-12-030 (48-15)
• Status: Completed
• Phase: N/A
• First received: March 12, 2012
• Last updated: March 12, 2012
• Start date: January 2010
• Est. completion date: December 2011

Study information

• Verified date: March 2012
• Source: Kwong Wah Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Hong Kong: Department of Health
• Study type: Observational

Clinical Trial Summary

The study hypothesize that parameters of new function machine---'forced oscillation technique' (FOT) can correlate well with the conventional lung function data for measurement of airway resistance and airtrapping in elderly COPD patients.

Description:

INTRODUCTION:

Forced oscillation technique (FOT) may be a good supplementary tool to assess lung function in elderly since it is a simple and fast tool requiring minimal patients' cooperation.

AIMS:

To investigate the accuracy of forced oscillation test FOT in assessment of airway resistance and airtrapping in elderly COPD patients by comparing FOT parameters to various conventional lung function parameters including FEV1, FEF 25-75, RV/TLC ratio, IC etc. The best FOT parameter for airway resistance and airtrapping is also determined.

STUDY DESIGN:

A cross-sectional study conducted in Kwong Wah Hospital, Hong Kong, SAR

METHODS:

COPD patients were recruited from 1st Jan, 2010 to 31st Dec 2011. Both of the lung function tests (forced oscillation technique (FOT) and conventional lung function test) were performed. Parameters of FOT (FRes FDep, RAvr, XAvr, were compared with conventional lung function test for assessment of both airway resistance and airtrapping in COPD subjects. Adjusted FOT parameters (FResRatio and FDep) were also compared with %FEV1 and different GOLD stages.

Statistics:

Comparison between FOT parameters and spirometric parameters was done by correlation test and expressed as Spearman coefficient. ANOVA test is used to compare FOT parameters among different groups of GOLD stages (stage 1 to 4) and groups with various degree of airtrapping (stage 1 to 3). Post hoc analysis was estimated by Bonferroni test.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 158
• Est. completion date: December 2011
• Est. primary completion date: December 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 60 Years to 90 Years

Eligibility

Inclusion Criteria:

• COPD patients with previous lung function tests confirming irreversible obstructive pattern

Exclusion Criteria:

• Lung function test failed to show any obstructive pattern

• Paitents with co-existing pulmonary diseases including asthma, interstitial lung diseases, lung malignancy etc.

• Patients with active infectious diseases like tuberculosis

Study Design

Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• COPD

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Kwong Wah Hospital