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NCT01226199 Clinical Trial

The Expression of TLR2 and TLR4 in the Lung of Chronic Obstructive Pulmonary Disease (COPD) Patients

COPD Clinical Trial

Official title:
The Expression of TLR2 and TLR4 in the Lung of COPD Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01226199
Other study ID # TLR2 and TLR4 in COPD tissue
Secondary ID
Status Recruiting
Phase N/A
First received October 21, 2010
Last updated June 7, 2011
Start date October 2010
Est. completion date March 2012

Study information
Verified date June 2011
Source Seoul National University Bundang Hospital
Contact Sei Won Lee, MD
Phone 82 31 787 7053
Email seiwon@snubh.org
Is FDA regulated No
Health authority South Korea: Korea Food and Drug Administration (KFDA)
Study type Observational

Clinical Trial Summary

Smoking is the most important risk factor of COPD, but only a fourth of smokers had COPD in their life. There are also healthy smokers without evidence of COPD. Investigators hypothesize that innate immunity may affect this difference between COPD patients and healthy smokers, because TLR4 is the receptor of LPS, which is the one of important substance in cigarette. Investigators will measure TLR2 and TLR4 expression in lung tissue of patients whose lung will be resected. Investigators will compare the level of expression between COPD patients and healthy smokers.

Recruitment information / eligibility
Status Recruiting
Enrollment 60
Est. completion date March 2012
Est. primary completion date December 2011
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- All patients who will have lung resection for the therapeutic cause.

Exclusion Criteria:

- Patients who do not agree with our study protocol

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Korea, Republic of Seoul National University Bundang Hospital Seongnam Gyeongi

Sponsors (1)
Lead Sponsor Collaborator
Seoul National University Bundang Hospital

Country where clinical trial is conducted

Korea, Republic of, 

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