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The Expression of TLR2 and TLR4 in the Lung of Chronic Obstructive Pulmonary Disease (COPD) Patients

COPD Clinical Trial

Official title:
The Expression of TLR2 and TLR4 in the Lung of COPD Patients

Clinical Trial Summary

Smoking is the most important risk factor of COPD, but only a fourth of smokers had COPD in their life. There are also healthy smokers without evidence of COPD. Investigators hypothesize that innate immunity may affect this difference between COPD patients and healthy smokers, because TLR4 is the receptor of LPS, which is the one of important substance in cigarette. Investigators will measure TLR2 and TLR4 expression in lung tissue of patients whose lung will be resected. Investigators will compare the level of expression between COPD patients and healthy smokers.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01226199
Study type Observational
Source Seoul National University Bundang Hospital
Contact Sei Won Lee, MD
Phone 82 31 787 7053
Email seiwon@snubh.org
Status Recruiting
Phase N/A
Start date October 2010
Completion date March 2012
View Details
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