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NCT00806091 Clinical Trial

Functional Proteomics of Alveolar Macrophages

COPD Clinical Trial

Official title:
Functional Proteomics of Alveolar Macrophages

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00806091
Other study ID # 2004H0102
Secondary ID
Status Completed
Phase
First received
Last updated
Start date July 2004
Est. completion date December 2008

Study information
Verified date October 2021
Source Ohio State University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to obtain young white blood cells (monocytes) from the investigators donated blood for research into how these cells change into large, mature white blood cells (macrophages) and how smoking causes Chronic Obstructive Pulmonary Disease (COPD).

Description:

Our research goal is to identify new targets and strategies to help care for patients with Chronic Obstructive Pulmonary Disease (COPD). COPD is a chronic airway inflammatory disorder characterized by a progressive loss of pulmonary function. Mononuclear phagocytes are known to be critically involved in both repair/remodeling and destructive events in COPD. Although smoking is the chief environmental risk factor for COPD, the molecular details responsible for the genesis and progression of smoking-mediated COPD require further investigation. In searching for new knowledge and research strategies for this challenging topic, we have made substantial progress in mononuclear phagocyte proteomics and laid the groundwork for this translational research of COPD.

Recruitment information / eligibility
Status Completed
Enrollment 72
Est. completion date December 2008
Est. primary completion date September 2008
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - COPD, smoker - COPD, non smoker Exclusion Criteria: - none

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States The Ohio State University Columbus Ohio

Sponsors (1)
Lead Sponsor Collaborator
Ohio State University

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary to define AM's pathogenic pathways underlying the development of COPD end of study
Secondary to determine protein polymorphism(s) that impact genetic susceptibility to COPD end of study
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