COPD Clinical Trial
Official title:
Noninvasive Ventilatory Support After Lung Surgery to Prevent Pulmonary Complications in COPD Patients
Rationale: respiratory complications are the most frequent complications following lung
resection and represent a noticeable cause of mortality. Benefits from non-invasive
ventilation (NIV) in acute respiratory failure are now clearly demonstrated. The use of
preventive NIV after lung resection, in the absence of acute respiratory failure and/or
hypercarbia, could be justified by the physiological benefits expected. The goal of this
study is to assess the efficacy of post-operative NIV in moderate-to-severe COPD, for
prevention of respiratory complications.
Material and Methods: This is a prospective randomised multicenter trial with an open
parallel design in moderate-t-o-severe COPD patients hospitalised in thoracic surgery for
lung resection.
Expected results: This study will determine whether post-operative NIV decreases the
incidence of acute respiratory events (acute respiratory failure) and whether some subgroups
of patients benefit more from this strategy.
Conclusion: This study should help evaluating the utility of post-operative NIV after lung
resection.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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