COPD & OSA Clinical Trial
Official title:
The Continuous Positive Airway Pressure Effects on Chronic Obstructive Pulmonary Disease Patients With Obstructive Sleep Apnea
1. The first objective of this study is to determine the differences between, while the
airway obstruction severity is the same, and the acute continuous positive airway
pressure (CPAP) effect on chronic obstructive pulmonary disease (COPD) patients with
overlap syndrome compared with COPD patients without in terms of sleep quality,
autonomic nerve activity, biologic markers of systemic inflammatory, and exercise
performance.
2. The second objective of this study is to evaluate the subacute (3 months treatment) CPAP
effect on COPD patients with overlap syndrome in terms of pulmonary hemodynamic and
right heart function, We will also determine the subacute effect of CPAP on sleep and
life quality, autonomic nerve activity, biologic markers of systemic inflammatory, as
well as exercise performance.
3. The last objective of this study is to evaluate the long term (12 months treatment) CPAP
effect on COPD patients with overlap syndrome. The un-scheduled clinic or emergency
department visiting, hospitalization, or mortality will be recorded to see if there is
significant treatment effect in terms of reducing morbidity and mortality. The long term
CPAP effect on sleep and life quality, autonomic nerve activity, biologic markers of
systemic inflammatory, exercise performance, as well as pulmonary hemodynamic and right
heart function will be re-evaluation.
COPD patients will be disturbed by season 12 months follow up is better than 18 months ;