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Platelet Activation and Reactivity in Acute Exacerbations of COPD

COPD Exacerbation Clinical Trial

Official title:
Platelet Activation and Responsiveness in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AE-COPD)

Clinical Trial Summary

Chronic obstructive pulmonary disease (COPD) is known for development of severe cardiovascular co-morbidities. Systemic inflammation during acute exacerbations of COPD (AE-COPD) is thought to play a role in development of cardiovascular disease. Platelets contribute to acute cardiovascular events and atherosclerosis. When platelets are activated, they form complexes with monocytes. These platelet-monocyte complexes (PMCs) are an early process in atherothrombosis and promote inflammation. In COPD, platelet function in AE-COPD is scarcely studied. This study aims to address this gap by investigating platelet function and coagulation in patients with AE-COPD and after convalescence.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03017625
Study type Observational
Source Radboud University
Contact Floor E Aleva, MD
Phone 0031 24 361 03 25
Email floor.aleva@radboudumc.nl
Status Not yet recruiting
Phase N/A
Start date January 2017
Completion date September 2017
View Details
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