Predictive Value of Osteopontin for Contrast Nephropathy

Status Not yet recruiting

Clinical Trial Summary

Early detection of contrast induced nephropathy by using osteopontin as an early marker for prediction

Clinical Trial Description

People who undergo coronary angiography are at risk of contrast-associated acute kidney injury (CA-AKI) . The prevention therapy is the main approach to address CA-AKI, minimizing the volume of contrast media and intravenous hydration before and after the procedure which may not be appropriate for those with heart failure . Given limited treatment options once CA-AKI develops and an unfavourable associated prognosis, early identification of those at risk of CA-AKI is crucial. Also, there is studies was linking CA-AKI with a higher mortality rate and adverse future cardiovascular events, and risk for future CA-AKI events . Mehran and colleagues described CA-AKI risk score predicting both CA-AKI and cardiovascular events after angiographic procedures. however, studies have also investigated the role of different biomarkers in prediction of AKI like osteopontin, in 2020, a consensus statement was released regarding how best to incorporate kidney biomarkers into clinical practice. Osteopontin is an extracellular structural protein synthesized by various cell types like osteoblasts, smooth muscle. and found in the loop of Henle and distal nephrons in normal kidneys. Recent studies have found that osteopontin has a critical role in tubulogenesis, cell apoptosis, promotion of cell regeneration. Lorenzen and colleagues found that critically ill patients with AKI have higher osteopontin concentrations than critically ill patients without AKI. Few studies have investigated the role of osteopontin in the detection of AKI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05547581
Study type	Observational
Source	Assiut University
Contact	Noura G. Nasr, Master
Phone	01096137766
Email	noura.victory@gmail.com
Status	Not yet recruiting
Phase
Start date	December 7, 2022
Completion date	December 8, 2024

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04877847` - Multi-Center Trial Utilizing Low Frequency Ultrasound in the Prevention of Post-Contrast Acute Kidney Injury	N/A
Recruiting	`NCT02088502` - Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced Nephropathy	Phase 2/Phase 3
Completed	`NCT03329443` - The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography	Phase 2
Recruiting	`NCT04864847` - Clinical Validation of the RENISCHEM L-FABP POC Assay
Completed	`NCT03627130` - The Use of Inorganic Nitrate for the Prevention of Contrast-induced Nephropathy	Phase 2
Active, not recruiting	`NCT03736018` - Randomised Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients	N/A
Withdrawn	`NCT04603261` - Time to Excretion of Contrast, a Maastricht Prospective Observational Study
Withdrawn	`NCT04598516` - Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30
Recruiting	`NCT03755700` - Vitamin E and N-acetylcysteine for Preventing Contrast-Induced Acute Kidney Injury After Coronary Artery Catheterization	Phase 3
Active, not recruiting	`NCT04606056` - Risk of Acute Kidney Injury After Intravenous Contrast Computed Tomography Scans
Terminated	`NCT02440646` - Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
Completed	`NCT00175227` - Prevention of Contrast-Induced Nephropathy	N/A
Completed	`NCT04014153` - CI-AKI in Patients With Stable CAD and Comorbidities. Are we Doing Better?
Withdrawn	`NCT04597892` - Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast
Completed	`NCT03305874` - Automated Prediction and Prevention of Contrast Induced Nephropathy After Cardiac Catheterization
Not yet recruiting	`NCT01871792` - Preventive Effect of Pitavastatin on Contrast-Induced Nephropathy in Patients With Renal Dysfunction	Phase 4
Not yet recruiting	`NCT06429345` - Coenzyme Q10 Role in Prevention of Contrast Induced Nephropathy in Acute Coronary Syndrome Patients.	Phase 4
Recruiting	`NCT05271448` - Continuing or Discontinuing ACE/ARBs in Patients With Chronic Kidney Disease Undergoing Coronary Angiography	N/A
Withdrawn	`NCT03806725` - Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
Completed	`NCT04163250` - Use of Urinary Cell-Cycle Arrest Biomarkers in Contrast-Associated Nephropathy After Coronary Angiography