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Contact Lens Discomfort clinical trials

View clinical trials related to Contact Lens Discomfort.

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NCT ID: NCT05548491 Completed - Clinical trials for Contact Lens Discomfort

Safety, Tolerability and Pharmacodynamics of AZR-MD-001 in Contact Lens Discomfort (CLD)

Start date: November 10, 2022
Phase: Phase 2
Study type: Interventional

A two stage, multi-center, vehicle-controlled study to determine common symptoms in patients with Contact Lens Discomfort (CLD) in Stage 1 and to evaluate the safety, tolerability, and pharmacodynamics of AZR-MD-001 in Stage 2.

NCT ID: NCT05416528 Completed - Questionnaire Clinical Trials

Chinese Translation and Validation of the 8-item Contact Lens Dry Eye Questionnaire (CLDEQ-8)

CLDEQ-8
Start date: November 18, 2022
Phase:
Study type: Observational

This is a cross-cultural adaptation, evaluation and validation study of the 8-item Contact Lens Dry Eye Questionnaire (CLDEQ-8) among soft contact lens wearers in China.

NCT ID: NCT03994406 Completed - Clinical trials for Contact Lens Discomfort

Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel

Start date: June 27, 2019
Phase: Phase 2
Study type: Interventional

This study compares contact lens comfortable wear duration, and signs and symptoms of contact lens discomfort, test versus control.

NCT ID: NCT03686878 Completed - Clinical trials for Contact Lens Discomfort

Lifitegrast 5% Ophthalmic Solution and Contact Lens Dryness

Start date: December 16, 2016
Phase: Phase 4
Study type: Interventional

The most common reason for contact lens discontinuation is contact lens discomfort. The investigators believe that inflammation plays a role in contact lens discomfort and the use of lifitegrast 5% ophthalmic solution may reduce end of the day contact lens discomfort. This study will enroll 21 contact lens users who will be receiving lifitegrast 5% ophthalmic solution and monitor the contact lens discomfort for a 8 week period while.

NCT ID: NCT03682809 Completed - Dry Eye Clinical Trials

Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort

Start date: November 19, 2018
Phase: Phase 4
Study type: Interventional

Clinicians commonly use artificial tears off label for treating contact lens (CL) discomfort and the dry eye associated with CLs because new artificial tear formulations have the potential to outperform the available CL rewetting drops. While off-label, McDonald et al. have previously shown that using a common artificial tear, Systane Ultra, before and after CL use is an effective means for treating daily disposable CL wears who have CL discomfort. Recently, a new formulation of artificial tears, Systane Complete, was released to the market. Systane Complete is a unique formulation that has combined elements from both Systane Ultra (indicated for aqueous deficient dry eye) and Systane Balance (indicated for evaporative dry eye) to create an artificial tear with an indication for aqueous deficient, evaporative, and mixed (both aqueous deficient and evaporative) dry eye. Thus, the goal of this study is to determine in a randomized clinical trial if Systane Complete is able to effectively improve the symptoms of patients who have CL discomfort.

NCT ID: NCT03311204 Completed - Clinical trials for Contact Lens Discomfort

The Effect of Eyelid Margin Debridement on Contact Lens Discomfort

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

In this study, clinical variables related to eyelids that potentially have an effect on contact lens discomfort will be investigated such as eyelid signs and secretions, eyelid sensitivity, eyelid microbiome, Demodex infestation and tear film properties. The main aim of this study is to understand the duration of efficacy of debridement of the eyelid margin and its impact on various eyelid signs (such as lid wiper epitheliopathy, lid-parallel conjunctival folds, eyelid sensitivity, meibomian gland morphology and meibum secretions, palpebral conjunctival reaction, eyelid microbiome and Demodex infestation, tear properties (both biophysical properties such as tear volume, tear meniscus height, tear evaporation, tear osmolarity and tear breakup time; and biochemical properties that are tear lipid analysis). To observe these variables, this study employs a cross-sectional design to study the effect of treatment at three instances, that is at baseline and two follow-up visits.

NCT ID: NCT02848222 Completed - Dry Eye Disease Clinical Trials

Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers

Start date: July 2016
Phase: N/A
Study type: Interventional

The purpose of this prospective study is to evaluate the benefits of using the Bruder Moist Heat Compress in contact lens wearers who report reduced comfortable wear time. This will be done by assessing for improvement in ocular oil gland function and comfortable contact lens wearing time after one month of daily warm compress application. The efficacy of the Bruder Moist Heat Compress applied once will be compared to twice daily application as well as compared to warm compress application using a wash cloth.