Constipation Clinical Trial
Official title:
A Feasibility Study to Measure Gut Transit in Paediatric Constipation Using Novel Mini-capsules and Magnetic Resonance Imaging
Constipation in children is a common problem. Managing these children is difficult, partly
because they do not respond to laxatives and partly because their bowel problem cannot be
defined. A "gut transit time" test can add information to help choose the best therapy but
this is often not carried out because of the unsuitable radiation dose involved in the
current methods such as X-ray. A new Magnetic Resonance Imaging (MRI) method to measure gut
transit time using inert mini-capsules, the size of small pine nuts, has recently been
developed.
This study is the first feasibility test of the new mini-capsules in paediatric constipation.
25 patients and 25 healthy controls will participate. The study will measure gut transit time
using MRI and the mini-capsules before and after the young patients receive standard
treatment.
One in ten children worldwide has constipation and it becomes chronic in 30% of these
children, affecting their and their families' well-being. Managing these children is
difficult, partly because they do not respond to laxatives and partly because their bowel
problem cannot be defined. If the doctors could send the children for a quick test that
indicates the time that food takes to travel through the gut (the "gut transit time"), they
could use this information to help choose the best therapy, for example to decide if a
patient needs surgery. The test could also be used to follow up the effects of different
treatments. Gut transit time is often not tested due to the unsuitable radiation dose
involved in the current methods such as X-ray. Doctors' decisions have to rely mostly on
symptoms, leading to repeated appointments, frustration and a waste of NHS money.
A new method to measure gut transit time using mini-capsules, the size of small pine nuts,
has recently been developed. The mini-capsules are swallowed but do not dissolve and their
journey through the gut is imaged using Magnetic Resonance Imaging (MRI). From the images
doctors can determine the gut transit time. MRI is harmless and can be used repeatedly to
follow up the response to treatment.
This study will test these new mini-capsules to determine their suitability for paediatric
use. Areas of interest are ease of imaging in the gut using MRI and whether they are small
enough such that their emptying from the stomach and transit through the gut are similar to
food. The study will test the mini-capsules in children with constipation, to measure gut
transit time before and after they receive their usual treatment from their doctors. This
will assess if the mini-capsules can detect changes in treatment and will make them
clinically useful.
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