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Constipation - Functional clinical trials

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NCT ID: NCT06404853 Completed - Clinical trials for Constipation - Functional

Effect and Safety of the Dietary Supplement Mannite in Pediatric Patients With Chronic Functional Constipation

MANNAPED
Start date: March 16, 2021
Phase: N/A
Study type: Interventional

Functional constipation is a widely prevalent pediatric issue, with a prevalence in some studies as high as 32.2%. Treatment consists of a combination of behavioral and pharmacological interventions (mainly, administration of polyethylene glycol laxatives or the use of enemas). Glucomannan (GNN) is a polysaccharide of 1,4-D-glucose and D-mannose found in the soluble fiber of some plants. While studies available in the literature to date agree that mannite is a dietary supplement with safe use, the usefulness of this compound remains controversial.

NCT ID: NCT05714410 Completed - Clinical trials for Constipation - Functional

Evaluation of Changes in Bowel Movement Frequency Following the Consumption of PHGG Compared to Placebo

TYPHOON-02
Start date: January 25, 2023
Phase: N/A
Study type: Interventional

Evaluation of Changes in Bowel Movement Frequency Following the Consumption of Partially Hydrolyzed Guar Gum (PHGG) in Adults With Constipation as Compared to Placebo (Typhoon 2)

NCT ID: NCT05541991 Completed - Clinical trials for Constipation - Functional

Study on the Effect of Rhubarb Extract on Stool Frequency and Biological Markers of Intestinal Function in Seniors With Low Defecation

Start date: February 10, 2017
Phase: N/A
Study type: Interventional

Randomized double-blind clinical study versus placebo evaluating the effect of supplementation with rhubarb extract on stool frequency and biological markers of intestinal function in seniors with a low number of defecations per week

NCT ID: NCT05447481 Completed - Clinical trials for Constipation - Functional

Evaluation of the Effect of Chicory Inulin-type Fructans in Constipated Adults

Start date: November 11, 2015
Phase: N/A
Study type: Interventional

Constipation is common in the general population, especially in women and in the elderly, which can significantly affect quality of life of the individual. There is a general consumer trend to seek natural food options, also when addressing health issues such as constipation. Consumers seek tasty options and there is a paucity of tasty functional foods to address constipation. Adding natural fiber to food, like inulin-type fructans from chicory root fiber, can increase fiber intake and potentially prevent or resolve constipation issues. This study aimed to increase the body of scientific data on inulin-type fructans by way of a randomized, placebo-controlled, cross-over study. Maltodextrin was used as the placebo in this study.

NCT ID: NCT05429333 Completed - Clinical trials for Constipation - Functional

Effect of Microbiome Modulation by Diet in Functional Constipation

Start date: December 14, 2020
Phase: N/A
Study type: Interventional

Current medications and behavioral modifications have limited success in the treatment of functional constipation (FC). An individualized diet based on microbiome analysis may improve symptoms in FC. In the present study, we aimed to investigate the impacts of microbiome modulation on chronic constipation. patients fulfilling Rome IV criteria for functional constipation were randomized into two groups. The Control group received sodium picosulfate plus conventional treatments (i.e., laxatives, enemas, increased fiber, and fluid intake). The study group underwent microbiome analysis and received an individualized diet with the assistance of a soft computing system (Enbiosis Biotechnology®, Sariyer, Istanbul). Differences in Patient Assessment Constipation-Quality of Life (PAC-QoL) score and complete bowel movements per week (CBMpW) were compared between groups after 6 week-intervention.

NCT ID: NCT05035784 Completed - Clinical trials for Fecal Microbiota Transplantation

RCE With FMT in the Treatment of Childhood Constipation

Start date: November 10, 2020
Phase: N/A
Study type: Interventional

Constipation is the most common complaint in childhood gastrointestinal disease, affecting an estimated 20% of the global children.The treatment strategies consist of diet control, behavioral intervention and oral and sometimes rectal laxatives. Given higher success rate and fewer side effects, the laxative PEG3350 has been considered the first choice in childhood constipation.However, effectiveness of PEG 3350 laxative is not lasting, and the use of PEG increases the risk of fecal incontinence. Additional treatment interventions are still necessary.Enema can act directly on the rectum and distal colon to quickly relieve symptoms of fecal impaction which is considered one of main source of intractable constipation. Children with fecal impaction who received enema had fewer fecal incontinence and diarrhea than children who received PEG. There have been lots of evidence that enema is effective in fecal impaction in children with functional constipation.But there are still cases of recurrences noted after enema. Fecal bacteria transplantation (FMT) is a new treatment method emerging in recent years, which is widely used in the treatment of functional gastrointestinal diseases. FMT has been proved to play a very prominent role in correcting intestinal flora disorders. By transplanting exogenous flora into the intestinal tract of patients, FMT can inhibit bacterial reproduction, regulate intestinal environment and cascade the body immunity, so as to achieve the therapeutic effect of disease. Retrograde colonic enema with FMT, an new method, provides the possibility for the treatment of childhood constipation. However, there is still a lack of evidence-based support for the treatment of childhood constipation by retrograde colonic enema with FMT. Therefore, we designed a randomized, controlled, double-blind clinical trial to confirm the efficacy and safety of retrograde colonic enema with FMT in the treatment of childhood constipation.

NCT ID: NCT05032534 Completed - Fecal Incontinence Clinical Trials

Examination of a New Irrigation System for Transanal Irrigation in Children With Fecal Incontinence

Start date: September 20, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to investigate if a new irrigation system for transanal irrigation (TAI) is effective and more tolerable than the currently used system at the Pediatric Ward at Aarhus University Hospital.

NCT ID: NCT04997187 Completed - Clinical trials for Constipation - Functional

Effect of Bacillus Coagulans in Adults With With Functional Constipation

Start date: July 20, 2021
Phase: N/A
Study type: Interventional

The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Bacillus coagulans on various symptoms and fecal microbial diversity in adults with with functional constipation for 12 weeks.

NCT ID: NCT04587635 Completed - Clinical trials for Constipation - Functional

Evaluation of Changes in Bowel Movement Frequency Following the Consumption of PHGG in Adults With Constipation

TYPHOON
Start date: September 16, 2020
Phase: N/A
Study type: Interventional

Evaluation of Changes in Bowel Movement Frequency Following the Consumption of Partially Hydrolyzed Guar Gum (PHGG) in Adults with Constipation

NCT ID: NCT03885973 Completed - Clinical trials for Constipation - Functional

Lactobacillus Plantarum IS 10560 Supplementation in Women With Functional Constipation

Start date: July 28, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

In this study, the investigators measured the SCFA (Butyrate, Acetate and Propionate) as a Biomarker improvement symptom and quality of life women with functional constipation after supplementation of commensal bacterial fermented milk Lactobacillus plantarum (isolated from indigenous probiotics from Dadih, West Sumatra) for 21 days