Consciousness Disorders Clinical Trial
Official title:
Phase 2 Study of a New Mechanical Ventilation Weaning Strategy Governs by a Respiratory Behaviour Status Assessment for Patients With Altered Level of Consciousness
The purpose of this study is to determine if a weaning strategy from artificial ventilation governs by respiratory behaviour status assessed by our method is safe enough.
Current guidelines for mechanical ventilation weaning do not apply for patients with altered level of consciousness. One major limitation is a failure of clinical assessment of the respiratory behaviour status of these patients that are not able to interact appropriately with the examiner. We propose a non-invasive method for the respiratory behaviour assessment of a patient under artificial ventilation that do not requires his participation. Our hypothesis is that, in case of normal respiratory behaviour status, it is possible to wean under security a patient despite his abnormal level of consciousness.We previously demonstrate that patients successfully wean by the clinical team also disclose a normal respiratory behaviour status while patients with weaning failure had abnormal respiratory behaviour. In the present study, we wonder to evaluate that a weaning strategy governs by respiratory behaviour status assessed by our method is safe. For this purpose, in this study, tracheal tube withdrawal is triggered by a recognition of a normal respiratory behaviour status assessed daily in patients under mechanical ventilation with an altered level of consciousness and a good tolerance to T tube challenge. ;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT06443827 -
Effect of Intravenous Amantadine Sulphate on Disorders of Consciousness
|
Phase 2 | |
Recruiting |
NCT02667899 -
The Consciousness Variation of Deep Brain and Transcranial Magnetic Stimulation for Disorders of Consciousness Patients
|
N/A | |
Completed |
NCT03060317 -
Validation of the Russian Version of Coma Recovery Scale-Revised (CRS-R)
|
N/A | |
Recruiting |
NCT06406413 -
Micro-movements in Patients With Prolonged Disorders of Consciousness
|
||
Not yet recruiting |
NCT06389344 -
Effect of Esketamine on Conscious State in Patients With pDoC
|
N/A | |
Terminated |
NCT02522429 -
Thalamic Low Intensity Focused Ultrasound in Brain Injury
|
N/A | |
Completed |
NCT02772302 -
Feasibility of mindBEAGLE in Disorders of Consciousness or Locked-In Syndrome
|
N/A | |
Recruiting |
NCT06088628 -
Micro-expressions in Patients With Prolonged Disorders of Consciousness
|
||
Recruiting |
NCT02714491 -
Effects of Auditory Stimulation During Verticalization With Erigo in Patients With Disorder of Consciousness
|
N/A | |
Terminated |
NCT03367078 -
tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
|
||
Completed |
NCT02828371 -
Early Stepping Verticalization in ICU for ABI Patients
|
N/A | |
Recruiting |
NCT06426615 -
Connectivity and Neural Signatures of Consciousness in Unresponsive States
|
N/A | |
Recruiting |
NCT06211439 -
Transcranial Alternating Current Stimulation in Patients With Disorders of Consciousness
|
N/A | |
Not yet recruiting |
NCT02659228 -
Assessing Covert Consciousness in Unresponsive Patients
|
N/A | |
Recruiting |
NCT02644265 -
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
|
||
Completed |
NCT01141790 -
Analysis of Vital, Facial and Muscular Responses Front to Music or Message in Coma, Vegetative State or Sedated Patients
|
N/A |