Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism

Status Completed

Clinical Trial Summary

This is a clinical study comparing targeted levothyroxine dosing based on thyroid anatomy as visualized on ultrasound (normal vs. ectopic/sublingual vs. athyreosis) to empiric levothyroxine dosing in infants with congenital hypothyroidism. Patients enrolled in the study for targeted dosing will be compared to controls obtained by retrospective chart review. The main outcome is to determine if there is a difference in the frequency of over-treatment and under-treatment during the first 6 months of therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02374593
Study type	Interventional
Source	Indiana University
Contact
Status	Completed
Phase	N/A
Start date	March 2014
Completion date	May 2016

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT01223638` - The Prevalence of Hearing Loss Among Children With Congenital Hypothyroidism	N/A
Completed	`NCT01916018` - Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	N/A
Recruiting	`NCT05687474` - Baby Detect : Genomic Newborn Screening
Completed	`NCT02307175` - A Study of 99m Tc Pertechnetate Produced in High Energy Cyclotron in Patients With Thyroid Scan Indication	N/A
Completed	`NCT00497575` - Diagnosis and Follow-up of Patients With Subclinical Hypothyroidism	N/A
Enrolling by invitation	`NCT03655223` - Early Check: Expanded Screening in Newborns
Completed	`NCT00403390` - Generic vs. Name-Brand Levothyroxine	N/A
Not yet recruiting	`NCT04734457` - Final Height in Patients With CH Diagnosed by the Screening
Completed	`NCT05371262` - Influence of Initial Levothyroxine Dose on Neurodevelopmental and Growth Outcomes in Congenital Hypothyroidism	Phase 4
Recruiting	`NCT00505479` - Iodine Status in Pregnant Women and Their Newborns: is Congenital Hypothyroidism Related to Iodine Deficiency in Pregnancy?	N/A
Completed	`NCT00493103` - TG Gene Mutations and Congenital Hypothyroidism	N/A
Active, not recruiting	`NCT05228184` - Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH)	Phase 4
Recruiting	`NCT04712760` - Congenital Hypothyroidism in Children With Eutopic Gland or Thyroid Hemiagenesis: Predictive Factors for Transient vs Permanent Hypothyroidism.
Completed	`NCT01488721` - Clinical Evaluation of NeoPlex4 Assay and NeoPlex System	N/A