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Congenital Hyperinsulinism clinical trials

View clinical trials related to Congenital Hyperinsulinism.

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NCT ID: NCT05171751 Completed - Clinical trials for Octreotide Adverse Reaction

Efficacy and Safety Evaluation of Octreotide in the Treatment of Congenital Hyperinsulinemia

BCH
Start date: November 1, 2021
Phase:
Study type: Observational

To analyze and evaluate the efficacy and safety of octreotide subcutaneous injection in the treatment of diazazine-ineffective congenital hyperinsulinemia (CHI) in children.

NCT ID: NCT04909333 Completed - Clinical trials for Endogenous Hyperinsulinism

Exenatide-test for Diagnosing Endogenous Hyperinsulinemic Hypoglycemia

FAST
Start date: April 29, 2021
Phase: N/A
Study type: Interventional

This study is to evaluate the concept of the exenatide test for diagnosis of EHH (earlier induction of symptomatic hypoglycemia compared to placebo within 4 hours after injection).

NCT ID: NCT04836273 Completed - Clinical trials for Postprandial Hypoglycemia

Treatment of Post-bariatric Hypoglycaemia

SHERRY
Start date: August 20, 2021
Phase: Phase 2
Study type: Interventional

This is an investigator-initiated, proof-of-concept, randomised, double-blind, placebo-controlled, single-centre phase II study aiming to evaluate the efficacy, safety and tolerability of self-administered subcutaneous 120 µg dasiglucagon with an investigational trial device (i.e. a multi-dose reusable pen) for the treatment of postprandial hypoglycaemia after Roux-en-Y gastric bypass (RYGB) surgery. The study is divided into an in-patient and out-patient part. The primary aim of the study is to compare the effects of self-administered 120 µg dasiglucagon versus placebo on continuous glucose monitoring (CGM)-assessed time spent in hypoglycaemia in RYGB-operated individuals in an out-patient setting.

NCT ID: NCT04652479 Completed - Clinical trials for Acquired Hyperinsulinemic Hypoglycemia

Avexitide Safety and Efficacy to Treat Acquired Hyperinsulinemic Hypoglycemia

Start date: June 21, 2021
Phase: Phase 2
Study type: Interventional

The primary goal of this study is to evaluate the safety and efficacy of two different dosing regimens of an investigational drug called Avexitide in treating low blood sugar in patients with Acquired Hyperinsulinemic Hypoglycemia.

NCT ID: NCT04538989 Completed - Clinical trials for Congenital Hyperinsulinism

An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism

Start date: February 24, 2020
Phase: Phase 2
Study type: Interventional

The objective of this trial is to evaluate the safety, tolerability and glucose-raising effects of RZ358 in patients with Congenital Hyperinsulinism (HI).

NCT ID: NCT04334161 Completed - Clinical trials for Roux-en-y Gastric Bypass

Evaluation of the Neuro-endocrine Response to Post-prandial Hyperinsulinaemic Hypoglycaemia.

DEEP1B
Start date: October 2, 2020
Phase:
Study type: Observational

The primary objective of this study is to assess the neuro-endocrine response to hypoglycaemia in PHH vs. non-PHH post-gastric bypass individuals.

NCT ID: NCT04330196 Completed - Clinical trials for Roux-en-Y Gastric Bypass

Effect of Postprandial Hyperinsulinaemic Hypoglycaemia on Driving Performance.

DEEP1C
Start date: July 8, 2020
Phase: N/A
Study type: Interventional

The primary objective of this study is to assess the effect of the natural course of postprandial hypoglycemia vs. a postprandial euglycaemic condition on driving performance in individuals with confirmed postprandial hyperinsulinaemic hypoglycaemia after gastric-bypass surgery.

NCT ID: NCT04172441 Completed - Clinical trials for Congenital Hyperinsulinism

Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital Hyperinsulinism

Start date: June 22, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

The objective of the trial is to evaluate the efficacy of dasiglucagon in reducing glucose requirements in children with persistent congenital hyperinsulinism (CHI) requiring continuous intravenous (IV) glucose administration to prevent/manage hypoglycemia.

NCT ID: NCT03984370 Completed - Clinical trials for Postprandial Hypoglycemia

Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass

Start date: September 18, 2019
Phase: Phase 2
Study type: Interventional

The aim of this study is investigating the effect of a novel glucagon analogue administration in gastric bypass operated individuals, who are reactive hypoglycemic.

NCT ID: NCT03777176 Completed - Clinical trials for Congenital Hyperinsulinism

A Two-Period Open-label Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital Hyperinsulinism

Start date: February 7, 2019
Phase: Phase 3
Study type: Interventional

The objective of the trial is to evaluate the efficacy and safety of dasiglucagon administered as a subcutaneous (SC) infusion in reducing hypoglycemia in children with CHI.